131966-80-8Relevant academic research and scientific papers
Paclitaxel delivery systems: The use of amino acid linkers in the conjugation of paclitaxel with carboxymethyldextran to create prodrugs
Sugahara, Shu-Ichi,Kajiki, Masahiro,Kuriyama, Hiroshi,Kobayashi, To-Ru
, p. 632 - 641 (2007/10/03)
Paclitaxel was bound via its hydroxyl group to carboxymethyldextran (CMDex, 150 kDa) by means of an amino acid linker; the linker was introduced into the 2′- or 7-hydroxyl group of the paclitaxel through an ester bond. These conjugates - CMDex-2′-paclitax
Synthesis and evaluation of some water-soluble prodrugs and derivatives of taxol with antitumor activity
Mathew,Mejillano,Nath,Himes,Stella
, p. 145 - 151 (2007/10/02)
The synthesis and evaluation of some 2'- and 7-amino acid derivatives of taxol (1) are reported. Reaction of taxol with N-protected amino acids gave 2'-N-protected amino acid esters of taxol. However, deprotection of the amino group and subsequent isolati
