1319726-95-8

Basic information

• Product Name: (1R,3R,4R,5R)-methyl 1-(4-chlorophenyl)-6-oxo-4-propyl-2-azaspiro[4.4]nonane-3-carboxylate
• CAS NO: 1319726-95-8
• Molecular Weight: 349.857
• Mol File: 1319726-95-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,3R,4R,5R)-methyl 1-(4-chlorophenyl)-6-oxo-4-propyl-2-azaspiro[4.4]nonane-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3R,4R,5R)-methyl 1-(4-chlorophenyl)-6-oxo-4-propyl-2-azaspiro[4.4]nonane-3-carboxylate(1319726-95-8)
• EPA Substance Registry System: (1R,3R,4R,5R)-methyl 1-(4-chlorophenyl)-6-oxo-4-propyl-2-azaspiro[4.4]nonane-3-carboxylate(1319726-95-8)

Safety Data

• Hazardous Substances Data: 1319726-95-8(Hazardous Substances Data)

Upstream product

• 56292-42-3 (E)-2-butylidene-1-cyclopentanone 
• 76862-09-4 methyl N-(4-chlorobenzylidene)glycinate 

Relevant articles and documents

Catalytic asymmetric construction of spirocycles containing pyrrolidine motifs and spiro quaternary stereogenic centers via 1,3-dipolar cycloaddition of azomethine ylides with 2-alkylidene-cycloketones

The first catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides with various sterically hindered α,α,β-trisubstituted 2-alkylidene-cycloketones has been developed successfully with silver acetate/TF-BiphamPhos complex for the construction of spiro heterocyclic compounds containing pyrrolidine motifs and a spiro quaternary stereogenic carbon center. The highly efficient catalytic system exhibited high reactivity, excellent diastereoselectivity, good enantioselectivity and broad substrate scope under mild conditions. Subsequent transformations led to the expedient preparation of synthetically useful spiro[pyrrolidine-tetrahydropyranone] and spiro[pyrrolidine-isochroman-1-one] without loss of the diastereo- and enantiomeric excesses. Copyright