131973-47-2

Basic information

• Product Name: Ethyl 5-hydroxy-5-(4-chlorophenyl)pent-2-enoate
• Synonyms: Ethyl 5-hydroxy-5-(4-chlorophenyl)pent-2-enoate
• CAS NO: 131973-47-2
• Molecular Weight: 254.713
• Mol File: 131973-47-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethyl 5-hydroxy-5-(4-chlorophenyl)pent-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-hydroxy-5-(4-chlorophenyl)pent-2-enoate(131973-47-2)
• EPA Substance Registry System: Ethyl 5-hydroxy-5-(4-chlorophenyl)pent-2-enoate(131973-47-2)

Safety Data

• Hazardous Substances Data: 131973-47-2(Hazardous Substances Data)

Upstream product

• 59425-01-3 ethyl (E)-4-iodobut-2-enoate 
• 104-88-1 4-chlorobenzaldehyde 
• 132017-27-7 C₂₄H₂₀B^(1-)*C₁₈H₃₆O₂Sb⁽¹⁺⁾ 

Downstream Products

• 15542-34-4 5-(4-chlorophenyl)penta-(2E,4E)-dienoic acid 

Relevant articles and documents

Pentaalkylstiboranes. 1. Synthesis of Homobenzylic Alcohols, Homoallylic Alcohols, Ethyl 5-Aryl-5-hydroxypent-2-enoates, and β-Hydroxypropionic Acid Derivatives via Pentaalkylstiboranes

Although pentaalkylstiboranes have long been known, their applications in organic synthesis have not been exploited.It has been found that quaternary stibonium salts (n-Bu3SbCH2E)+X- (E = Ph, CH=CH2, CH=CHCO2Et, CO2Et, CN; X = Br, I, BPh4) on treatment with RLi (R = n-Bu, t-Bu, Ph) afford pentaalkylstiboranes, n-Bu3Sb(R)CH2E, which react with aromatic aldehydes to give, after subsequent hydrolysis, homobenzylic alcohols, homoallylic alcohols, ethyl 5-aryl-5-hydroxypent-2-enoates, and β-aryl-β-hydroxypropionitriles, respectively, in good to excellent yields.The reaction is chemoselective for aldehydes.