1319744-31-4

Basic information

• Product Name: 3-(4-nitrophenyl)-N-(quinolin-8-yl)propanamide
• Synonyms: 3-(4-nitrophenyl)-N-(quinolin-8-yl)propanamide
• CAS NO: 1319744-31-4
• Molecular Weight: 321.335
• Mol File: 1319744-31-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-nitrophenyl)-N-(quinolin-8-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-nitrophenyl)-N-(quinolin-8-yl)propanamide(1319744-31-4)
• EPA Substance Registry System: 3-(4-nitrophenyl)-N-(quinolin-8-yl)propanamide(1319744-31-4)

Safety Data

• Hazardous Substances Data: 1319744-31-4(Hazardous Substances Data)

Upstream product

• 60666-01-5 (RS)-N-phthaloyl-p-nitrophenylalanine 
• 578-66-5 8-amino quinoline 

Downstream Products

• 1319744-14-3 3-(4-nitrophenyl)-N-(8-quinolinyl)-5-(triisopropylsilyl)-4-pentynamide 

Relevant articles and documents

Directing Group Participated Benzylic C(sp3)-H/C(sp2)-H Cross-Dehydrogenative Coupling (CDC): Synthesis of Azapolycycles

An efficient method to construct azapolycycles via directing group participated benzylic C(sp3)-H/C(sp2)-H cross-dehydrogenative coupling reactions is described. The reaction proceeded through a palladium catalyzed C(sp3)-H activation followed by coupling with a C(sp2)-H bond of quinoline to afford the azapolycyclic compounds. The reaction works with a broad substrate scope affording the products in moderate to good yields with excellent diastereoselectivities. Control experiments further supported the proposed mechanism.