1319746-46-7

Basic information

• Product Name: (Z)-3-Fluoro-N'-hydroxybenzene-1-carboxiMidaMide
• Synonyms: (Z)-3-Fluoro-N'-hydroxybenzene-1-carboxiMidaMide;(Z)-3-FLUORO-N-HYDROXYBENZIMIDAMIDE
• CAS NO: 1319746-46-7
• Molecular Formula: C7H7FN2O
• Molecular Weight: 154.1416832
• Mol File: 1319746-46-7.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 249.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.30±0.1 g/cm3(Predicted)
• PKA: 14.08±0.50(Predicted)
• CAS DataBase Reference: (Z)-3-Fluoro-N'-hydroxybenzene-1-carboxiMidaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-Fluoro-N'-hydroxybenzene-1-carboxiMidaMide(1319746-46-7)
• EPA Substance Registry System: (Z)-3-Fluoro-N'-hydroxybenzene-1-carboxiMidaMide(1319746-46-7)

Safety Data

• Hazardous Substances Data: 1319746-46-7(Hazardous Substances Data)

Usage

Uses

(Z)-3-Fluoro-N''-hydroxybenzene-1-carboximidamide

Upstream product

• 501-00-8 3-fluorophenylacetonitrile 
• 403-54-3 m-Fluorobenzonitrile 
• 24964-64-5 3-Cyanobenzaldehyde 
• 1073-06-9 3-fluorobromobenzene 
• 72505-20-5 3-fluorobenzene-1-carbothioamide 

Downstream Products

• 1422682-35-6 ethyl 2-(3-fluorophenyl)-1H-imidazole-4-carboxylate 
• 1630015-69-8 3-(3-fluoro-phenyl)-5-(2-nitro-3-methylphenyl)-1,2,4-oxadiazole 
• 1338667-43-8 3-(3-fluorophenyl)-5-(3-indazolyl)-1,2,4-oxadiazole 
• 1630015-61-0 3-(3-fluorophenyl)-5-(6-indazolyl)-1,2,4-oxadiazole 
• 1630015-57-4 3-(3-fluorophenyl)-5-(5-indazolyl)-1,2,4-oxadiazole 
• 1630015-53-0 3-(3-fluorophenyl)-5-(4-indazolyl)-1,2,4-oxadiazole 
• 1154180-95-6 3-(3-fluoro-phenyl)-5-(2-amino-3-methylphenyl)-1,2,4-oxadiazole 
• 1630015-65-4 3-(3-fluorophenyl)-5-(7-indazolyl)-1,2,4-oxadiazole 
• 1403775-96-1 tert-butyl 3-(3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate 
• 75908-00-8 5-(3,3-Dinitrobutyl)-3-(3-fluorophenyl)-1,2,4-oxadiazole 

Relevant articles and documents

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPKɑ1β1γ1 activators

Adenosine monophosphate-activated protein kinase (AMPK) plays a key role in maintaining whole-body homeostasis and has been regarded as a therapeutic target for the treatment of diabetic nephropathy (DN). Herein, a series of 1,2,4-oxadiazole-containing py

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

KCNT1 INHIBITORS AND METHODS OF USE

The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.