131993-08-3Relevant academic research and scientific papers
Novel antiallergic and antiinflammatory agents. Part I: Synthesis and pharmacology of glycolic amide derivatives
Ban, Masakazu,Taguchi, Hiroaki,Katsushima, Takeo,Takahashi, Mitsuru,Shinoda, Kiyotaka,Watanabe, Akihiko,Tominaga, Takanari
, p. 1069 - 1076 (1998)
A series of mono-glycoloylamino derivatives was synthesized by treatment of the corresponding aromatic monoamine derivatives with glycoloyl chloride derivatives in pyridine or dichloromethane, in the presence of a base such as triethylamine or pyridine. Hydrolysis of acetoxy compounds in aqueous ammonia and methanol solution produced hydroxy derivatives with ease. These compounds were tested in the rat PCA (passive cutaneous anaphylaxis) assay by oral administration. Thiazole and thiadiazole derivatives showed moderate inhibition in this assay. In contrast, benzothiazole and benzonitrile derivatives exhibited marked inhibition. In particular, compound 5t also showed marked inhibition of eosinophil adhesion to TNF (tumor necrosis factor) -α-treated HUVEC (human umbilical vein endothelial cells) in the range of 10-8-10-5M. Copyright (C) 1998 Elsevier Science Ltd.
Novel substituted acetamide compounds and use as anti-allergic agents
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, (2008/06/13)
Novel substituted acetamide compounds of the formula STR1 wherein R1 is hydrogen atom, a lower alkyl group, a lower acyl group, or an aryl group; R2 is cyano group or aminocarbonyl group; R3 is a halogen atom, nitro group,
