132015-06-6Relevant academic research and scientific papers
ENANTIOSPECIFIC SYNTHESIS AND ABSOLUTE CONFIGURATION OF β-LACTAM INTERMEDIATES FROM 2-AMINO-1-PHENYL-1,3-PROPANEDIOLS
Gunda, Tamas E.,Vieth, Siegfried,Koever, Katalin E.,Sztaricskai, Ferenc
, p. 6707 - 6710 (2007/10/02)
The aldimines derived from (1S,2S)-2-amino-1-phenyl-1,3-propanediols as chiral starting materials were used to prepare cis-β-lactams (3, 4) via the Staudinger-reaction.High diastereoselectivity was reached only with large silyl protecting groups.The 6 oxazine derivative was obtained when using butyryl chloride as ketene precursor.
