132017-68-6

Upstream product

• 10349-38-9 p-methoxyphenylisonitrile 
• 34886-50-5 (5-iodopent-1-yn-1-yl)benzene 
• 53293-00-8 hex-5-ynoic acid 
• 540803-88-1 6-phenylhex-5-ynoic acid N-(4-methoxyphenyl)amide 
• 540803-87-0 6-phenylhex-5-ynoic acid 
• 540803-95-0 6-phenylhex-5-ynethioic acid N-(4-methoxyphenyl)amide 

Relevant academic research and scientific papers

Domino N2-Extrusion-Cyclization of Alkynylarylketone Derivatives for the Synthesis of Indoloquinolines and Carbocycle-Fused Quinolines

New synthetic approaches for the synthesis of indoloquinolines and carbocycle-fused quinolines have been developed employing alkynylketone substrates. These synthetic transformations involved the application of N2-extrusion of azido complexes as a key step to generate carbodiimidium ion and nitrilium ion in situ, which further cyclized intramolecularly with alkyne via a domino process to provide indoloquinolines and carbocycle-fused quinolines, respectively, in moderate to good yields.

Synthesis of carbocyclic and heterocyclic fused quinolines by cascade radical annulations of unsaturated N-aryl thiocarbamates, thioamides, and thioureas.

[reaction: see text] Tandem radical cyclizations of suitably substituted N-aryl thiocarbamates, thioamides, and thioureas are induced by exposure to tris(trimethylsilyl)silane (TTMSH) and UV light and provide furoquinolines, isofuroquinolines, cyclopentaq

4 + 1 Radical Annulations with Isonitriles: A Simple Route to Cyclopenta-Fused Quinolines

Sunlamp irradiation of 1-substituted 5-iodo-1-pentynes, 5 equiv of phenyl isocyanide, and 1.5 equiv of hexamethylditin in tert-butylbenzene (0.01-0.025 M) at 150°C produces 9-substituted 2,3-dihydro-1H-cyclopenta[b]quinolines in 36-70% yields. A mechanist