132019-26-2Relevant academic research and scientific papers
Bleomycin-Mediated Degradation of Aristeromycin-Containing DNA. Novel Dehydrogenation Activity of IronII-Bleomycin
Sugiyama, Hiroshi,Sera, Takashi,Dannoue, Yukihiro,Marumoto, Ryuji,Saito, Isao
, p. 2290 - 2295 (2007/10/02)
The antitumor antibiotic bleomycin (BLM) induces C-H bond scission at the C4′ of deoxyribose moiety of DNA in the presence of Fe(II) and O2. To investigate the primary oxidation step, 2′-deoxyaristeromycin (Ar) possessing a cyclopentane ring in
