1320281-50-2Relevant articles and documents
Mannopyranosyl uronicaAcid donor reactivity
Walvoort, Marthe T. C.,De Witte, Wilbert,Van Dijk, Jesse,Dinkelaar, Jasper,Lodder, Gerrit,Overkleeft, Herman S.,Codee, Jeroen D. C.,Van Der Marel, Gijsbert A.
, p. 4360 - 4363 (2011/10/18)
The reactivity of a variety of mannopyranosyl uronic acid donors was assessed in a set of competition experiments, in which two (S)-tolyl mannosyl donors were made to compete for a limited amount of promoter (NIS/TfOH). These experiments revealed that the reactivity of mannuronic acid donors is significantly higher than expected based on the electron-withdrawing capacity of the C-5 carboxylic acid ester function. A 4-O-acetyl-β-(S)-tolyl mannuronic acid donor was found to have similar reactivity as per-O-benzyl-α-(S)-tolyl mannose.