1320343-77-8Relevant articles and documents
Pyridine-derived γ-secretase modulators
Wan, Zehong,Hall, Adrian,Sang, Yingxia,Xiang, Jia-Ning,Yang, Eric,Smith, Beverley,Harrison, David C.,Yang, Guang,Yu, Haihua,Price, Helen S.,Wang, Jian,Hawkins, Julie,Lau, Lit-Fui,Johnson, Matthew R.,Li, Tina,Zhao, Wei,Mitchell, William L.,Su, Xiaobo,Zhang, Xiaomin,Zhou, Yanjiao,Jin, Yun,Tong, Zhaolong,Cheng, Ziqiang,Hussain, Ishrut,Elliott, John D.,Matsuoka, Yasuji
, p. 4832 - 4835 (2011/09/16)
SAR of a novel series of pyridine-derived γ-secretase modulators is described. Compound 5 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain (or increase) the levels of total Aβ. Furthermore, representative compounds 1 and 5 demonstrated in vivo efficacy to lower Aβ42 in the brain without altering Notch processing in the peripheral.
