1320362-49-9

Upstream product

• 766-97-2 4-n-methylphenylacetylene 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 1256286-01-7 4-iodo-1-methoxy-3-(p-tolyl)-1H-pyrano[4,3-b]quinoline 
• 292638-85-8 acrylic acid methyl ester 
• 1159765-59-9 2-(2-(p-tolyl)ethynyl)quinoline-3-carbaldehyde 

Relevant academic research and scientific papers

2-(1-benzotriazolyl)pyridine: A robust bidentate ligand for the palladium-catalyzed C-C (Suzuki, Heck, Fujiwara-Moritani, Sonogashira), C-N and C-S coupling reactions

A new class of bidentate ligand, 1-(pyridine-2-yl)-1H-benzo[d][1,2,3] triazole has been designed and employed for the palladium-catalyzed C-C (Suzuki, Heck, Fujiwara-Moritani, and Sonogashira), C-N and C-S coupling reactions. The ligand was found to be inexpensive, thermally stable, easy to synthesize from easily accessible starting materials on a multigram scale, show simplicity in use, and robustness in application, making this ligand effective for different coupling reactions. Suitably, the donor ability of the N=N bond of the benzotriazole ring and lone pair of electrons on the N of the pyridine ring enhance the bidentate ability of the ligand.

Pyrano[4,3-b]quinolines library generation via iodocyclization and palladium-catalyzed coupling reactions

Synthesis of a 80-member library of novel pyrano[4,3-b]quinolines in solution-phase is reported. The key intermediate, 4-iodopyrano[4,3-b]quinolines were synthesized by the electrophilic iodocyclization of corresponding ortho-alkynyl aldehydes in good to