13206-60-5Relevant articles and documents
Synthesis of aryl aldimines and their activity against fungi of clinical interest
da Silva, Cleiton M.,da Silva, Danielle L.,Martins, Cleide V.B.,de Resende, Maria A.,Dias, Esther S.,Magalhaes, Thais F.F.,Rodrigues, Leticia P.,Sabino, Adao A.,Alves, Rosemeire B.,de Fatima, Angelo
, p. 810 - 815 (2011)
Aldimines are aldehyde-derived compounds that contain a C=N group. Besides its broad industrial applications, this class of non-naturally occurring compounds are found to possess antibacterial, antifungal, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Based on this, six aryl aldimines were synthesized from the condensation of aromatic amines with benzaldehydes. The antifungal activities of synthesized compounds were evaluated against nineteen fungal strains that included Candida and Aspergillus species, Cryptococcus neoformans. The aryl aldimines 2-(benzylideneamino)phenol (3) and 4-(benzylideneamino)phenol (8) were the most active compounds against the fungi studied. Compounds 3 and 8 efficiently inhibited the metabolism of C. neoformans mature biofilm.
Transfer hydrogenation of aldehydes and ketones catalyzed using an aminophosphinite POCNHpincer complex of Ni(ii)
?ztop?u, ?zgür,Hayrapetyan, Davit,Khalimon, Andrey Y.,Lyssenko, Konstantin A.,Segizbayev, Medet,Shakhman, Dinmukhamed
, p. 11950 - 11957 (2020/09/21)
The aminophosphinite pincer complex (POCNH)NiBr was found to effectively catalyze the transfer hydrogenation of aldehydes and ketones with 2-propanol and KOtBu as a base, presenting a rare example of bifunctional nickel transfer hydrogenation catalysts. The transfer hydrogenation of aldehydes and ketones was found to be selective, tolerating a wide range of other functional groups, including those prone to reduction, such as esters, amides, alkenes, pyridines, and nitriles. The reactions were suggested to proceedviathe metal-ligand cooperative mechanism with an intermediacy of an amido (POCN)NiIIspecies.
The evaluation of the role of C-H?F hydrogen bonds in crystal altering the packing modes in the presence of strong hydrogen bond
Kaur, Gurpreet,Singh, Sandhya,Sreekumar, Amritha,Choudhury, Angshuman Roy
, p. 154 - 169 (2015/11/18)
Interactions involving fluorine is an area of contemporary research. To unravel the importance of weak C-H?F hydrogen bonds and C-H?π interactions in organic compounds in the presence of strong hydrogen bond, a series of N-benzylideneanilines with simultaneously hydroxyl (-OH) and fluorine substitutions were synthesized for structural analysis. These compounds have been studied through experimental single crystal X-ray diffraction analysis and computational methods (Gaussian09 and AIM2000). The hydroxyl group present in all the molecules were found to form strong O-H?N hydrogen bond, but the spatial arrangement of the molecules connected by this hydrogen bond have been found to be controlled by the weak C-H?F and C-H?O hydrogen bonds, weak C-H?π and π?π interactions. This manuscript illustrates the importance of several weaker interactions in altering the packing modes in the presence of strong hydrogen bonds.
Synthesis, characterization, and oxidation of new POCNimine-type pincer complexes of nickel
Mougang-Soum, Berline,Belanger-Garipy, Francine,Zargarian, Davit
supporting information, p. 5990 - 6002 (2015/02/19)
This report describes the synthesis and characterization of new pincer-type complexes of divalent and trivalent nickel. Refluxing toluene mixtures of NiBr2(CH3CN)n and the unsymmetrical pincer-type ligands Ph-POCH/su
