13208-68-9Relevant academic research and scientific papers
Method for synthesizing asymmetric disubstituted urea through catalytic oxidation and carbonylation
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Paragraph 0055; 0056, (2017/12/28)
The invention discloses a novel method for directly synthesizing asymmetric disubstituted urea compounds. The method comprises the step of adding a palladium catalyst into a solvent polyethylene glycol or a polyethylene glycol water solution under the action of alkali, an iodine compound and an oxidant so as to catalyze direct cross coupling reaction of primary amine and carbon monoxide, so as to prepare the asymmetric disubstituted urea compounds. The method for preparing the asymmetric disubstituted urea compounds through the coupling reaction has the advantages that the catalyst is wide in source and environment-friendly; a substrate is wide in source, cheap and easy to process; a carbonyl is stable in source and cheap and does not generate waste; a ligand is not required in the reaction, and the reaction activity is good; reaction conditions are mild, and the reaction selectivity is high; the substrate has good functional group consistency and is wide in application range; and a reaction medium is environment-friendly and can be circularly recycled. The separation yield of a target product can reach up to about 97% under optimized reaction conditions.
THE INTRAMOLECULAR NH...Cl HYDROGEN BOND IN UREA DERIVATIVES CONTAINING THE o-CHLOROPHENYL GROUP
Mido, Yoshiyuki,Okuno, Tomoko
, p. 29 - 34 (2007/10/02)
The solution ν(N-H) vibrations of various disubstituted ureas containing a halophenyl group have been examined in order to directly confirm the presence of an intramolecular NH...Cl hydrogen bond in the o-chloro analog.In chlorophenyl derivatives the ν(N-
