132087-74-2Relevant academic research and scientific papers
SYNTHESIS OF &β-LACTAM DERIVATIVES OF 1,5-BENZOXAZEPINES AND 1,5-BENZOTHIAZEPINES
Torrini, Ines,Zecchini, Giampiero Pagani,Paradisi, Mario Paglialunga,Scazzocchio, Francesca
, p. 1687 - 1691 (2007/10/02)
Condensed β-lactam derivatives of 1,5-benzoxazepines (2a-i) and of 1,5-benzothiazepines (2j-r) have been synthesized by the reaction of quinobenzoxazepines (1a-c) or the corresponding benzothiazepines (1d-f) with some acyl chlorides in the presence of triethylamine.The formyl chloroacetamido derivatives (4a,b) were instead obtained by treating 1a,d with chloroacetyl chloride in the absence of the base.The mechanism of the reactions is discussed.No antibacterial activity was shown by the title compounds (2a-r) in the test experimental conditions.
