132112-35-7

Basic information

• Product Name: Ropivacaine hydrochloride
• Synonyms: Ropivacaine Hydrochloride (200 mg);1-methy1-1h-tetrazol-5-ylthiol;Ropivacaine Hcl monohydrate;(S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate;Ropivacaine Hydrochloride, USP;Ropivacaine-(S) Hydrochloride;Ropivacaine HCl.H2O;Ropivacaine hydrochloride hydrate
• CAS NO: 132112-35-7
• Molecular Formula: C₁₇H₂₆N₂O*ClH*H₂O
• Molecular Weight: 328.88
• EINECS: 1533716-785-6
• Product Categories: Inhibitors;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 132112-35-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 267-269°C
• Boiling Point: 410.2 °C at 760 mmHg
• Flash Point: 201.9 °C
• Appearance: white to off-white/
• Vapor Pressure: 1.18E-10mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: H2O: soluble5mg/mL, clear
• CAS DataBase Reference: Ropivacaine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Ropivacaine hydrochloride(132112-35-7)
• EPA Substance Registry System: Ropivacaine hydrochloride(132112-35-7)

Safety Data

• Hazard Codes: T,Xi
• Statements: 26/27/28-41
• Safety Statements: 22-36/37/39-45-39-26
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 132112-35-7(Hazardous Substances Data)

Usage

Description

(–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve. (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine . Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth.

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 132112-35-7 differently. You can refer to the following data:
1. Anesthetic (local)
2. Anesthetic (local).
3. Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

Definition

ChEBI: The monohydrate form of (S)-ropivacaine hydrochloride.

General Description

Ropivacaine has lidocaine-related structure with tertiary amine side chains.?It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.

Biochem/physiol Actions

Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.

InChI:InChI=1/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2

Synthetic route

ropivacaine (84057-95-4) → ropivacaine hydrochloride monohydrate (132112-35-7)

Conditions	Yield
With hydrogenchloride; water In acetone pH=2; Product distribution / selectivity; Heating / reflux;	82%
With hydrogenchloride; water at 0 - 85℃; for 48h; Product distribution / selectivity;	79%

ropivacaine hydrochloride (98717-15-8) → ropivacaine hydrochloride monohydrate (132112-35-7)

Conditions	Yield
With water at 40℃; for 20h; Product distribution / selectivity;

Upstream product

• 84057-95-4 ropivacaine 
• 98717-15-8 ropivacaine hydrochloride 

Related news

Analgesic, hemodynamic and respiratory effects of caudal epidurally administered Ropivacaine hydrochloride (cas 132112-35-7) in mares07/31/2019

Objective To determine the analgesic, hemodynamic and respiratory effects, sedation and ataxia in mares of caudal epidural administration of ropivacaine hydrochloride solution.Study design Prospective, single-dose trial.Animals Ten healthy mares weighing from 475 to 565 kg.Methods Intravascular ...detailed

The effects of Ropivacaine hydrochloride (cas 132112-35-7) on the expression of CaMK II mRNA in the dorsal root ganglion neurons07/28/2019

In this study, we identified the subtype of Calcium/calmodulin-dependent protein kinase II (CaMK II) mRNA in dorsal root ganglion neurons and observed the effects of ropivacaine hydrochloride in different concentration and different exposure time on the mRNA expression. Dorsal root ganglion neur...detailed

Relevant articles and documents

Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom

The present invention describes a novel process of preparation of optically pure L-Pipecolic acid and an improved process for the conversion of L-pipecolic acid to L-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, its hydrochloride salt and hydrochloride monohydrate.