1321199-85-2Relevant academic research and scientific papers
Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues
Gemma, Sandra,Kunjir, Sanil,Sanna Coccone, Salvatore,Brindisi, Margherita,Moretti, Vittoria,Brogi, Simone,Novellino, Ettore,Basilico, Nicoletta,Parapini, Silvia,Taramelli, Donatella,Campiani, Giuseppe,Butini, Stefania
, p. 5949 - 5953 (2011/10/09)
Here we report the synthesis and evaluation of antiplasmodial activity of a novel series of bicyclic peroxides inspired by the marine natural compound dihydroplakortin. We developed a synthetic strategy leading to the dihydroplakortin-related peroxides in only a few steps. The in vitro antiplasmodial potency of the peroxides was similar to, or greater than, that of the reference natural compound, and structure-activity relationship studies revealed several key structural requirements for activity and potency.
