132141-40-3Relevant academic research and scientific papers
Synthesis of 6-aminophenanthridines via palladium-catalyzed insertion of isocyanides into N-sulfonyl-2-aminobiaryls
Jiang, Huanfeng,Gao, Hanling,Liu, Bifu,Wu, Wanqing
, p. 17222 - 17225 (2014)
A robust route to a diverse set of 6-aminophenanthridines via palladium-catalyzed C-H activation of N-sulfonyl-2-aminobiaryl and isocyanide insertion is reported. This transformation could also provide an important approach for building core frameworks of conjugated organic polymer materials.
Synthesis of imidazo[1,2-f]phenanthridine derivatives under a metal- and base-free condition and their anticancer activity
Narva, Suresh,Zhang, Mi,Li, Ce,Chen, An,Tanaka, Yoshimasa,Zhang, Wen
, (2021)
A series of imidazo[1,2-f]phenanthridine derivatives were synthesized from phenanthridin-6-amine and aldehydes through sulfur endorsed oxidative cyclization reaction under a metal- and base-free condition with atom economy strategy and evaluated their anticancer activity. Among all the synthesized derivatives, the compound 3d and 3f exhibited IC50 values of 2.18 ± 0.08 and 2.24 μM ± 0.71 μM, respectively. Compound 3d had the strongest inhibitory activity against HT-29 cells with an IC50 value being 1.25 μM ± 0.22 μM, which was even stronger than that of paclitaxel.
Electrochemical Cyclization of 1-Phenyl-2(-1'-chlorophenyl)-substituted Five-membered Nitrogen Heterocycles. Application to the Synthesis of Phenanthridines
Grimshaw, James,Hewitt, S. Armstrong
, p. 2995 - 2998 (2007/10/02)
Pyrrolophenanthridine (compound 4), 3-phenylimidazophenanthridine 8, tetrazolophenanthridine 11 and benzotetrazolophenanthridine 12 have been prepared using an electrochemical cyclizatin procedure.Treatment of the imidazophenanthridine with singlet oxygen yields a phenanthridone by degradation of the heterocyclic system.Lithium aluminium hydride reduction of the tetrazolophenanthridines yields the phenanthridine.
