1321619-06-0

Basic information

• Product Name: N-(3-fluoro-4-(2-(methylsulfonyl)-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
• Synonyms: N-(3-fluoro-4-(2-(methylsulfonyl)-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
• CAS NO: 1321619-06-0
• Molecular Weight: 614.586
• Mol File: 1321619-06-0.mol

Chemical Properties

• CAS DataBase Reference: N-(3-fluoro-4-(2-(methylsulfonyl)-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoro-4-(2-(methylsulfonyl)-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide(1321619-06-0)
• EPA Substance Registry System: N-(3-fluoro-4-(2-(methylsulfonyl)-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide(1321619-06-0)

Safety Data

• Hazardous Substances Data: 1321619-06-0(Hazardous Substances Data)

Upstream product

• 1979-98-2 4,6-dihydroxy-2-methylmercaptopyrimidine 
• 399-96-2 4-amino-2-fluorophenol 
• 10428-49-6 β-chloro-β-nitrostyrene 
• 1321619-03-7 N-(3-fluoro-4-(2-(methylthio)-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1336879-44-7 C₁₉H₁₄FN₃O₂S 
• 1301610-62-7 4-chloro-2-(methylthio)-5-phenylfuro[2,3-d]pyrimidine 
• 1301610-61-6 2-methylthio-5-phenylfuro[2,3-d]pyrimidin-4(3H)-one 

Downstream Products

• 1321619-09-3 N-(3-fluoro-4-(2-methoxy-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1321619-07-1 N-(3-fluoro-4-(2-(methylamino)-5-phenylfuro[2,3-d]pyrimidin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 

Relevant articles and documents

Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d] pyrimidine or furo[2,3-d]pyrimidine scaffold

A series of thieno[2,3-d]pyrimidines and furo[2,3-d]pyrimidines were synthesized and evaluated for the c-Met inhibition. Thieno[2,3-d]pyrimidine 6b stood out as the most potent showing an IC50 of 35.7 nM. This compound displayed high inhibitory effect on cell proliferation in BaF3-TPR-Met cells and showed high selectivity for c-Met family against other 14 tested kinases. However, compound 6b was found ineffective in the c-Met-dependent U-87MG human gliobastoma xenograft model that may be relevant to its poor PK profile.