132168-97-9

Basic information

• Product Name: 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl diphenylacetate
• CAS NO: 132168-97-9
• Molecular Weight: 448.562
• Mol File: 132168-97-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl diphenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl diphenylacetate(132168-97-9)
• EPA Substance Registry System: 2-(2-(2-propyl)-1,3-dioxo-2,8-diazaspiro<4,5>decane-8-yl)ethyl diphenylacetate(132168-97-9)

Safety Data

• Hazardous Substances Data: 132168-97-9(Hazardous Substances Data)

Upstream product

• 1716-11-6 diphenylacetic acid sodium salt 
• 132168-96-8 8-(2-chloroethyl)-2-(2-propyl)-2,8-diazaspiro<4,5>decane-1,3-dione 

Relevant articles and documents

POTENTIAL CHOLINERGIC AND ANTICHOLINERGIC COMPOUNDS: SYNTHESIS OF 2,8-SUBSTITUTED 2,8-DIAZASPIRODECANE-1,3-DIONES

Heating the ammonium salt of (4-carboxy-1-methyl-4-piperidinyl)acetic acid (XII) gave 8-methyl-2,8-diazaspirodecane-1,3-dione (II) which was N-alkylated with 2-bromoethanol and 4-bromobutanol to give the alcohols III and V.Compound III was transformed to the chloro compound VI which was reacted with the sodium salt of hexahydrobenzilic acid to give the ester VII.Compound V was transformed to the 4-toluenesulfonic ester VIII which reacted with 1-(2-pyrimidinyl)piperazine and gave IX. 2-(2-Propyl)-2,8-diazaspirodecane-1,3-dione (XVIII) was similarly transformed via XIX to XX which reacted with the sodium salts of diphenylacetic, benzilic, hexahydrobenzilic, and (2-oxo-1-pyrrolidinyl)acetic acid to give the esters XXI-XXIV.The esters VII and XXI-XXIV were transformed to the methiodides.The compounds prepared were tested in the lines of activity of the analogous "RS-86" (I) but proved inactive.