Welcome to LookChem.com Sign In|Join Free

CAS

  • or

132194-28-6

Post Buying Request

132194-28-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

132194-28-6 Usage

General Description

9-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-3H-purine-2,6-dione, also known as 9-[(2R,5S)-5-(Hydroxymethyl)furan-2-yl]-3H-purine-2,6-dione, is a chemical compound with the molecular formula C13H14N4O5. It is a purine nucleoside analog that has potential antiviral and antitumor properties. 9-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-3H-purine-2,6-dione inhibits the activity of viral enzymes and DNA polymerases, leading to the suppression of viral replication and tumor cell proliferation. It is also being investigated for its potential use in the treatment of diseases such as HIV, hepatitis B, and various cancers. Studies have shown that this compound exhibits promising activity against a range of viral and tumor cell lines, making it a potential candidate for the development of new antiviral and anticancer drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 132194-28-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,1,9 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 132194-28:
(8*1)+(7*3)+(6*2)+(5*1)+(4*9)+(3*4)+(2*2)+(1*8)=106
106 % 10 = 6
So 132194-28-6 is a valid CAS Registry Number.

132194-28-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-2,6-dione

1.2 Other means of identification

Product number -
Other names 2',3'-Dideoxyxanthosine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:132194-28-6 SDS

132194-28-6Upstream product

132194-28-6Downstream Products

132194-28-6Relevant articles and documents

Escherichia coli mediated biosynthesis and in vitro anti-HIV activity of lipophilic 6-halo-2',3'-dideoxypurine nucleosides

Murakami,Shirasaka,Yoshioka,Kojima,Aoki,Ford Jr.,Driscoll,Kelley,Mitsuya

, p. 1606 - 1612 (2007/10/02)

A series of 6-substituted 2',3'-dideoxypurine ribofuranosides (ddP) was enzymatically synthesized with live E. coli in an effort to enhance the lipophilicity of this class of anti-human immunodeficiency virus (HIV) compounds and thereby facilitate drug delivery into the central nervous system. All 6-halo-substituted ddPs were substantially more lipophilic, as defined by their octanol-water partition coefficient (P), than their nonhalogenated congeners 2',3'-dideoxyinosine (ddI) or 2',3'-dideoxyguanosine (ddG). For this class of compounds, log P's ranged from +0.5 to -1.2 in the following order: 6-iodo, 2-amino-6-iodo > 6-bromo, 2-amino-6-bromo > 6-chloro, 2-amino-6-chloro > 6-fluoro, 2-amino-6-fluoro >> ddG > ddI. These compounds were evaluated in vitro for ability to suppress the infectivity, replication, and cytopathic effect of HIV. 2-Amino-6-fluoro-, 2-amino-6-chloro-, and 6-fluoro-ddP exhibited a potent activity against HIV comparable to that of ddI or ddG and completely blocked the infectivity of HIV without affecting the growth of target cells. The comparative order of in vitro anti-HIV activity was 2-amino-6-fluoro, 2-amino-6-chloro, 6-fluoro > 2-amino-6-bromo > 2-amino-6-iodo, 6-chloro > 6-bromo > 6-iodo. These compounds also exhibited potent in vitro activity against HIV-2 and 3'-azido-3'-deoxythymidine-resistant HIV-1 variants. All 2-amino-6-halo-ddPs and 6-halo-ddPs were substrates for adenosine deaminase (ADA) and were converted to ddG or ddI, respectively. In the presence of the potent ADA inhibitor 2'-deoxycoformycin, 6-halo-substituted ddPs failed to exert an in vitro antiretroviral effect. These dideoxypurine nucleoside analogues represent a new class of lipophilic prodrugs of ddG and ddI that possess the potential for more effective therapy of HIV-induced neurologic disorders.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 132194-28-6