132194-31-1

Basic information

• Product Name: 4-hydroxyphenylnaftodipil
• Synonyms: 4-hydroxyphenylnaftodipil
• CAS NO: 132194-31-1
• Molecular Formula: C24H28N2O4
• Molecular Weight: 408.49012
• Mol File: 132194-31-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 647.6°C at 760 mmHg
• Flash Point: 345.4°C
• Appearance: /
• Density: 1.239g/cm³
• Vapor Pressure: 1.18E-17mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: 4-hydroxyphenylnaftodipil(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxyphenylnaftodipil(132194-31-1)
• EPA Substance Registry System: 4-hydroxyphenylnaftodipil(132194-31-1)

Safety Data

• Hazardous Substances Data: 132194-31-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C24H28N2O4/c1-29-24-15-19(27)9-10-22(24)26-13-11-25(12-14-26)16-20(28)17-30-23-8-4-6-18-5-2-3-7-21(18)23/h2-10,15,20,27-28H,11-14,16-17H2,1H3

Upstream product

• 57149-07-2 naftopidil 
• 2461-42-9 3-(1-naphthyloxy)-1,2-epoxypropane 
• 129338-90-5 1-(2-methoxy-4-hydroxyphenyl)piperazine 

Relevant articles and documents

Synthesis of potential Naftopidil metabolites

The synthesis of four proposed metabolites 1-4 of Naftopidil, a selective α1-antagonist, is reported. These compounds comprise hydroxylated and demethylated derivatives and a cleavage product of Naftopidil.

Piperazine derivatives, uses thereof and pharmaceutical compositions containing them

The present invention provides compounds of the general formula: STR1 wherein R1 is a hydroxyl group or a methoxy radical, R2 is a hydrogen atom or a hyroxyl group and R3 is a hydrogen atom or a hydroxyl group, with the proviso that R2 and R3 are not simultaneously hydrogen atoms when R1 is a methoxy radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.