1321984-37-5Relevant articles and documents
Indolin-2-one p38α inhibitors I: Design, profiling and crystallographic binding mode
Eastwood, Paul,González, Jacob,Gómez, Elena,Vidal, Bernat,Caturla, Francisco,Roca, Ramón,Balagué, Cristina,Orellana, Adelina,Domínguez, María
, p. 4130 - 4133 (2011)
The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38α inhibitors. The predicted binding mode was confirmed by X-ray crystallography.