132203-11-3Relevant articles and documents
Synthesis of (+)-biotin: Efficient resolution of key intermediates
Bihovsky,Bodepudi
, p. 7667 - 7676 (1990)
Enantiomerically pure 4-chlorothieno[3,4-d]imidazol-2-one (+)-2 and thieno[3,4-d]imidazol-2,4-dione (+)-5, key intermediates in independent routes to (+)-biotin (6), have been prepared by resolution via the corresponding diastereomeric ethers (3d-g and 3'd-g). Efficient procedures to recycle the undesired diastereomers and recover the chiral auxiliary have been developed.