1322076-89-0Relevant academic research and scientific papers
Chiral Primary Amine Organocatalysts for Syn-selective Asymmetric Cross-Aldol Reactions
Gao, Qiang,Liu, Yan,Lu, Shengmei,Li, Can
, p. 899 - 903 (2011)
Based on the "acid-base" interaction strategy, organocatalysts for the asymmetric cross-aldol reaction were synthesized by the in situ combination of chiral primary amines with protonic acids. Unlike general secondary amine catalysts that give anti-selective products, as-prepared primary amine catalysts can give syn-selective cross-aldol products with high yield and high selectivity (up to 90% yield, 90:10 syn/anti ratio, 90% ee). Compared with the complex synthesis of the reported catalysts, the primary amine catalyst that gave the best results was easily prepared using commercial available (1S,2S)-(+)-cyclohexanediamine.
Chiral primary amine organocatalysts for syn-selective asymmetric cross-aldol reactions
Gao, Qiang,Liu, Yan,Lu, Shengmei,Li, Can
experimental part, p. 899 - 903 (2012/06/18)
Based on the "acid-base" interaction strategy, organocatalysts for the asymmetric cross-aldol reaction were synthesized by the in situ combination of chiral primary amines with protonic acids. Unlike general secondary amine catalysts that give anti-selective products, as-prepared primary amine catalysts can give syn-selective cross-aldol products with high yield and high selectivity (up to 90 yield, 90:10 syn/anti ratio, 90 ee). Compared with the complex synthesis of the reported catalysts, the primary amine catalyst that gave the best results was easily prepared using commercial available (1S,2S)-(+)-cyclohexanediamine.
