1322077-35-9

Basic information

• Product Name: C₄₄H₅₇NO₇S
• Synonyms: C₄₄H₅₇NO₇S
• CAS NO: 1322077-35-9
• Molecular Weight: 744.005
• Mol File: 1322077-35-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₄H₅₇NO₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₄H₅₇NO₇S(1322077-35-9)
• EPA Substance Registry System: C₄₄H₅₇NO₇S(1322077-35-9)

Safety Data

• Hazardous Substances Data: 1322077-35-9(Hazardous Substances Data)

Upstream product

• 324763-39-5 (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane 
• 187324-64-7 (1S,2R)-2-[N-benzyl-N-(mesitylenesulfonyl)amino]-1-phenyl-1-propanol 
• 1322077-30-4 C₁₉H₃₀O₅ 
• 1322077-28-0 C₂₄H₃₈O₇ 

Downstream Products

• 1322077-39-3 C₅₁H₆₇NO₉S 
• 1322077-41-7 C₂₆H₄₀O₇ 
• 1351987-42-2 C₂₆H₃₉NO₆ 
• 1236549-00-0 {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-furanidin-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-carbamic acid benzyl ester 
• 1236549-06-6 (1S,2S,4S)-4-(2-carbamoyl-2-methylpropyl-carbamoyl)-2-hydroxy-1-{(S)-2-[4-methoxy-3-(3-methoxypropoxy)-benzyl]-3-methylbutyl}-5-methylhexyl-carbamic acid benzyl ester 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 

Relevant articles and documents

A new synthesis of the orally active renin inhibitor aliskiren

A convergent synthesis of the orally active renin inhibitor aliskiren (1) is described. The synthesis was accomplished in 12 steps starting from the known chloride 2. The key step involves the Curtius rearrangement of the advanced intermediate 15, which provides lactone/carbamate 17 containing the correct stereochemistry and all of the functionality required for the preparation of the drug substance.