1322091-23-5

Basic information

• Product Name: 5-fluoro-2-(p-tolylethynyl)benzaldehyde
• Synonyms: 5-fluoro-2-(p-tolylethynyl)benzaldehyde
• CAS NO: 1322091-23-5
• Molecular Formula: C₁₆H₁₁FO
• Molecular Weight: 238.2563432
• EINECS: -0
• Mol File: 1322091-23-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 372.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 5-fluoro-2-(p-tolylethynyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2-(p-tolylethynyl)benzaldehyde(1322091-23-5)
• EPA Substance Registry System: 5-fluoro-2-(p-tolylethynyl)benzaldehyde(1322091-23-5)

Safety Data

• Hazardous Substances Data: 1322091-23-5(Hazardous Substances Data)

Upstream product

• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 766-97-2 4-n-methylphenylacetylene 

Downstream Products

• 1338721-79-1 dimethyl 10-fluoro-6-(p-tolyl)-4-tosyl-3,4-dihydro-2H-pyridazino[6,1-a]isoquinoline-1,1(11bH)-dicarboxylate 
• 1322091-33-7 1,3-dicyclohexyl-1-(7-fluoro-3-p-tolylisoquinolin-1-yl)-2-tosylguanidine 
• 1364406-17-6 (S)-8-bromo-3-fluoro-4b,5-dihydro-12-p-tolylisoquinolino[2,1-a]quinazolin-6-one 
• 1364406-15-4 (S)-3-fluoro-4b,5-dihydro-12-p-tolylisoquinolino[2,1-a]quinazolin-6-one 
• 1448038-61-6 13-fluoro-9-(p-tolyl)-14b,16-dihydrobenzo[6,7]indolo[3′,4′:3,4,5]azepino[2,1-a]isoquinoline 
• 1448038-75-2 13-fluoro-9-(p-tolyl)-14b,16-dihydroindolo[3′,4′:3,4,5]pyrido[2′,3′:6,7]azepino[2,1-a]isoquinoline 

Relevant articles and documents

Completely Stereoselective Synthesis of Sulfonated 1,3-Dihydroisobenzofurans via Radical Multicomponent Reactions

Two types of new oxidant-free radical multicomponent reactions of β-alkynyl ketones, aryldiazonium salts, and DABCO·(SO2)2 (DABSO) were established, leading to the tunable generation of two class of sulfonated 1,3-dihydroisobenzofurans with moderate to good yields and complete stereoselectivity under the mild conditions. The radical-induced scission/recombination of the C(sp3)-C(sp3) bond enabled direct 1,8-halosulfonylation of β-alkynyl ketones, giving 1,3-dimethylene-substituted (1Z,3Z)-1,3-dihydroisobenzofurans with substituent diversity by p-nitrobenzyl bromide (PNBB) or p-nitrobenzyl chloride (PNBC) as the halo source. Fine-tuning substituents to strong electron-withdrawing ones, such as nitro, cyano, and trifluoromethyl, linked to aryldiazonium tetrafluoroborates allowed a different annulation/1,5-azosulfonylation process to access sulfonated (Z)-1,3-dihydroisobenzofurans with one quaternary carbon-amino functionality.

Gold-Catalyzed Reaction of ortho-Alkynylarylaldehydes with Conjugated Dienes: An Efficient Access to Highly Strained Tetracyclic Bridgehead Olefins

An unprecedented access to strained tetracyclic bridgehead alkenes by reaction of easily accessible ortho-alkynylarylaldehydes with conjugated dienes is described. The process involves a chemo- and stereo-selective, gold-catalyzed, tandem intermolecular [3+2] cycloaddition/Prins-type ring-closing reaction that allows generating structural complexity in a straightforward manner. This approach for the preparation of anti-Bredt compounds is synthetically superior to those previously reported: the procedure is easy to implement, operates under mild experimental conditions, is efficient, and exhibits a good substrate scope.

Tuning the reactivity of Au-complexes in an Au(i)/chiral Bronsted acid cooperative catalytic system: An approach to optically active fused 1,2-dihydroisoquinolines

An enantioselective cooperative catalysis protocol, utilizing achiral Au(i) complexes and chiral Bronsted acids, has been developed for the synthesis of optically pure fused 1,2-dihydroisoquinolines starting from 2-alkynylbenzaldehydes and 2-aminobenzamides. The Royal Society of Chemistry 2012.