13222-10-1

Basic information

• Product Name: 8-quinolinylbenzenesulfonate
• Synonyms: 8-quinolinylbenzenesulfonate
• CAS NO: 13222-10-1
• Molecular Formula: C₁₅H₁₁NO₃S
• Molecular Weight: 285.31774
• Mol File: 13222-10-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-quinolinylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 8-quinolinylbenzenesulfonate(13222-10-1)
• EPA Substance Registry System: 8-quinolinylbenzenesulfonate(13222-10-1)

Safety Data

• Hazardous Substances Data: 13222-10-1(Hazardous Substances Data)

Upstream product

• 148-24-3 8-quinolinol 
• 98-09-9 benzenesulfonyl chloride 

Relevant articles and documents

Targeting DNA binding for NF-κB as an anticancer approach in hepatocellular carcinoma

Quinoline core has been shown to possess a promising role in the development of anticancer agents. However, the correlation between its broad spectrum of bioactivity and the underlying mechanism of actions is poorly understood. The present study, with the

NMR study of O and N, O-substituted 8-quinolinol derivatives

The 1H and 13C NMR spectral study of several biologically active derivatives of 8-quinolinol have been made through extensive NMR studies including homodecoupling and 2D-NMR experiments such as COSY-45°, NOESY, and HeteroCOSY. Electron donating resonance and electron withdrawing inductive effect of several groups showed marked changes in chemical shifts of nuclei at the seventh positions of O-substituted quinolinols (2-15). Although in N-alkyl, 8-alkoxyquinolinium halides (16-21), ring A rightly showed low frequency chemical shift values. Copyright

In vitro studies of the antibacterial and antifungal activity of oxime and its derivatives

Twenty-one derivatives of 8-hydroxyquinoline (oxine, 8H, CAS 148-24-3) were prepared and characterized by UV, IR, MS and NMR spectroscopy. Four of these derivatives, N-butyl, 8-butyloxyquinolinium bromide (HBD), 8-pentyloxyquinoline (HPEM), N-pentyl, 8-pentyloxyquinolinium bromide (HPED) and N-benzyl, 8-benzyloxy quinolinium chloride (HBED) are new and reported for the first time. The antimicrobial activity of these compounds was carried out in vitro against 11 Gram positive and 18 Gram negative bacteria, and 18 fungi including 9 dermatophytes, 7 other filamentous fungi and 2 Candida species. Three compounds namely, HPRD, HPED and HBED were found to possess significant antibacterial activity in order of HPED > HPRD > HBED, whereas 4 were found to possess significant antifungal activity in order of 8H > HT > HPEM > 8B.