1322261-67-5

Upstream product

• 863036-33-3 3-phenyl-N-(2,2,2-trichloro-1-isothiocyanato-ethyl)-acrylamide 
• 90-04-0 2-methoxy-phenylamine 
• 16535-67-4 (2E)-3-phenyl-N-[1-hydroxy-2,2,2-trichloroethyl]-2-acrylamide 
• 621-79-4 cinnamamide 
• 102-92-1 Cinnamoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 

Relevant academic research and scientific papers

SAR, cardiac myocytes protection activity and 3D-QSAR studies of salubrinal and its potent derivatives

Salubrinal is a selective inhibitor of endoplasmic reticulum (ER) stress and affords remarkable protection to cardiomyocytes. By studying the structure-activity relationship (SAR) of salubrinal, it was found that modification of the quinoline ring terminus and thiourea unit could confer the compound PP1-24 with markedly enhanced cardioprotective activity (EC 50 2 = 0.741, r2 = 0.991).