13224-84-5Relevant articles and documents
Formal Synthesis of (±)-Aplykurodinone-1 Based on the Indium-Catalyzed Conia-Ene Reaction
Wang, Xiaoji,Zhou, Yi,Xiao, Hesheng,Ou, Wentao,Pang, Yiying,Li, Wang,Wang, Liping,Huang, Shuangping
, p. 1404 - 1408 (2020)
A concise formal synthesis of (±)-aplykurodinone-1 starting from a commercially available material and based on the indium-catalyzed Conia-ene reaction has been accomplished. The synthesis features a Riley selenium dioxide oxidation, a Krapcho dealkoxycarbonylation, and a ring-closing metathesis approach. The synthetic strategy was also supported by a Saegusa oxidation and a classic Michael 1,4-conjugate addition.
Catalytic use of chiral phosphine ligands in asymmetric Pauson-Khand reactions
Hiroi, Kunio,Watanabe, Takashi,Kawagishi, Ryoko,Abe, Ikuko
, p. 797 - 808 (2000)
Catalytic asymmetric Pauson-Khand reactions with chiral bidentate phosphines as ligands have been successfully accomplished. The catalytic use of (S)-BINAP as a ligand was demonstrated to be the most effective in the cobalt-catalyzed reactions of 1,6-enyn
Total synthesis and structural revision of laurefurenynes A and B
Holmes, Michael T.,Britton, Robert
, p. 12649 - 12652 (2013)
Structural reassignment: A total synthesis of the proposed structure of (-)-laurefurenynea A has been accomplished that relies on organocatalytic aldehyde α-chlorination and a flexible chlorohydrin-based strategy for stereocontrolled access to the bis-tetrahydrofuran core of the natural product. Analysis of incongruities between the 1Ha NMR spectra of synthetic and natural material led to a configurational reassignment for the natural product, which was also confirmed by total synthesis. Copyright
Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines
Luo, Xiaosheng,Wang, Ping
supporting information, p. 4960 - 4965 (2021/07/20)
Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.
INTRACELLULAR DELIVERY VEHICLE
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Paragraph 0296, (2019/05/18)
An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
