13225-34-8

Basic information

• Product Name: 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE
• Synonyms: 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE;1-(3-Methoxyphenyl)-4-oxocyclohexanecarbonitrile
• CAS NO: 13225-34-8
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.277
• Mol File: 13225-34-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE(13225-34-8)
• EPA Substance Registry System: 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE(13225-34-8)

Safety Data

• Hazardous Substances Data: 13225-34-8(Hazardous Substances Data)

Usage

General Description

4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE is a chemical compound with the molecular formula C15H17NO2. It is a cyclohexanone derivative with a cyano group and a methoxyphenyl group attached to the cyclohexane ring. 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE is commonly used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It has a wide range of potential applications due to its diverse chemical properties and functional groups. 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE may be used in research and development, as well as in the production of various commercial products. Additionally, it is important to handle this chemical with caution and follow proper safety protocols due to its potential hazards.

Upstream product

• 13225-33-7 5-Cyano-5-(3-methoxy-phenyl)-2-oxo-cyclohexanecarboxylic acid methyl ester 
• 19924-43-7 3-methoxyphenylacetonitrile 
• 13216-65-4 γ-Cyan-γ-(3-methoxy-phenyl)-pimelinsaeure-methylester 

Downstream Products

• 13225-35-9 8-(3-methoxy-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 850885-64-2 cis-4-[(diphenylmethyl)amino]-1-(3-methoxyphenyl)-cyclohexanecarbonitrile 
• 850885-65-3 trans-4-[(diphenylmethyl)amino]-1-(3-methoxyphenyl)-cyclohexanecarbonitrile 
• 867263-58-9 tert-butyl [({[cis-4-amino-1-(3-methoxyphenyl)-cyclohexyl]methyl}amino)sulfonyl]carbamate 

Relevant articles and documents

PHARMACEUTICAL COMPOUNDS

This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated

NOVEL PIPERIDINE DERIVATIVE

The invention provides a compound of the following formula (1): wherein m, n, and p are independently an integer of 0 - 4, provided 3 ≤ m + n ≤ 8; X is nitrogen atom or a group of the formula: C-R15; Y is a substituted or unsubstituted aromatic group, etc.; R15, R1, R2, R3, R4 , R5, R6 and R7 are hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and Z is hydrogen atom, cyano group, etc., or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which exhibits an action for enhancing LDL receptor expression, and is useful as a medicament for treating hyperlipidemia, atherosclerosis, etc.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.