13225-34-8

Usage

Uses

Used in Pharmaceutical Industry:
4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure and functional groups make it a valuable component in the synthesis of new drug molecules, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE serves as a key intermediate in the synthesis of agrochemicals. Its chemical properties allow for the creation of compounds that can be used in the development of pesticides, herbicides, and other agricultural products to enhance crop protection and yield.
Used in Research and Development:
4-CYANO-4-(3-METHOXYPHENYL)CYCLOHEXANONE is utilized in research laboratories for the exploration of new chemical reactions and the synthesis of novel compounds. Its presence in the scientific community aids in the discovery of innovative applications and the expansion of chemical knowledge.
Used in Commercial Product Manufacturing:
This chemical compound is also employed in the production of various commercial products, leveraging its diverse chemical properties to create a range of consumer goods, from specialty chemicals to high-performance materials.

Upstream product

• 19924-43-7 3-methoxyphenylacetonitrile 
• 13216-65-4 γ-Cyan-γ-(3-methoxy-phenyl)-pimelinsaeure-methylester 
• 13225-33-7 5-Cyano-5-(3-methoxy-phenyl)-2-oxo-cyclohexanecarboxylic acid methyl ester 

Downstream Products

• 65619-83-2 4-cyano-4-(m-hydroxyphenyl)cyclohexanone 
• 13225-35-9 8-(3-methoxy-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 867264-42-4 cis-1-(3-methoxyphenyl)-4-[(1-tritylpiperidin-4-yl)amino]-cyclohexanecarbonitrile 
• 867264-20-8 N-[cis-4-cyano-4-(3-ethoxyphenyl)cyclohexyl]biphenyl-4-carboxamide 
• 867264-18-4 N-[cis-4-cyano-4-(3-methoxyphenyl)cyclohexyl]biphenyl-4-carboxamide 
• 867264-19-5 N-[cis-4-cyano-4-(3-hydroxyphenyl)cyclohexyl]biphenyl-4-carboxamide 
• 850886-02-1 tert-butyl 4-{[cis-4-cyano-4-(3-methoxyphenyl)cyclohexyl]amino}piperidine-1-carboxylate 
• 850886-33-8 cis-4-[(biphenyl-4-ylmethyl)amino]-1-(3-methoxyphenyl)-cyclohexanecarbonitrile 
• 850885-66-4 cis-4-amino-1-(3-methoxyphenyl)-cyclohexanecarbonitrile 

Relevant academic research and scientific papers

PHARMACEUTICAL COMPOUNDS

This invention relates to compounds that are agonists of the muscarinic M1 receptor or M1 and M4 receptors and which are useful in the treatment of muscarinic M1 or M1/M4 receptor mediated

SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

NOVEL SULFONAMIDE DERIVATIVE

A compound of the formula (1): wherein m, n and p is independently an integer of 0 to 4 with the proviso that 3 a?| m + n a?| 8; X is the formula: NR4, etc.; R1, R3 and R4 are a substituted or unsubstituted aryl group, etc.; R2 is a hydrogen atom, etc.; a, b, c, d, e and f are a hydrogen atom or a substituted or unsubstituted alkyl group, etc.; Y is the formula: -SO2-, etc.; and Z is an oxygen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt of the same has an activity of potentiating an expression of a low density lipoprotein receptor and thus is useful as an agent for treating hyperlipidemia or arteriosclerosis.

NOVEL PIPERIDINE DERIVATIVE

The invention provides a compound of the following formula (1): wherein m, n, and p are independently an integer of 0 - 4, provided 3 ≤ m + n ≤ 8; X is nitrogen atom or a group of the formula: C-R15; Y is a substituted or unsubstituted aromatic group, etc.; R15, R1, R2, R3, R4 , R5, R6 and R7 are hydrogen atom, a substituted or unsubstituted alkyl group, etc.; and Z is hydrogen atom, cyano group, etc., or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which exhibits an action for enhancing LDL receptor expression, and is useful as a medicament for treating hyperlipidemia, atherosclerosis, etc.

4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues.Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated.Synthesis starts by double Michael reaction of acrylate on arylacetonitriles.Following cyclization, decarboxylation, ketalization, and saponification, the geminally substituted acid is rearranged to the isocyanate by means of (C6H5O)2PON3.Isocyanates were then converted to the title compounds.Analgesic activity is very sensitive to the nature and position of the substituent on the aromatic ring.The most potent compounds in this series (p-CH3, p-Br) showed 50percent the potency of morphine.Deletion of the ring oxygen abolishes activity.

Analgetic compounds, compositions and process of treatment

Novel compounds of the formula: STR1 wherein R1 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, CH2 -alkenyl wherein alkenyl is from 2 to 4 carbon atoms, inclusive, cycloalkyl of from 3 to 6 carbon atoms, inclusive, cycloalkylmethyl of from 3 to 6 carbon atoms, inclusive; R2 is a variable consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, inclusive, with the proviso that R1 and R2 cannot both be hydrogen at the same time; Y is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive, halogen, trifluoromethyl, hydroxy, alkanoyloxy from 2 to 5 carbon atoms, inclusive, alkoxy of from 1 to 4 carbon atoms, inclusive, cycloalkyloxy of from 3 to 6 carbon atoms, inclusive, benzyloxy; m is an integer 0, 1, 2; R5 is a variable consisting of hydrogen and alkyl of from 1 to 4 carbon atoms, inclusive; R3 is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive; R4 is a variable consisting of alkyl of from 1 to 4 carbon atoms, inclusive, CH2 -alkenyl wherein alkenyl is of from 2 to 4 carbon atoms, inclusive, and arylalkyl wherein alkyl is from 1 to 4 carbon atoms, inclusive, and aryl is STR2 WHEREIN Y' is CF3, halogen, alkyl of 1 to 4 carbon atoms, inclusive, and alkoxy of from 1 to 4 carbon atoms, inclusive; and R3 and R4 when taken together with the nitrogen atom to which they are attached can form saturated heterocycles of from 5 to 7 ring members, a second hetero atom of said ring can be oxygen or nitrogen, e.g., morpholine, piperazine, and said heterocycles can be monosubstituted having a total of up to 9 carbon atoms, with the proviso that when STR3 is pyrrolidinyl, then m = 1, 2, having analgetic activity in humans and animals are prepared in unit dosage forms. The compositions are useful in relieving pain by administering orally, parenterally, and rectally to humans and animals.