132252-85-8Relevant academic research and scientific papers
Synthesis, reactions, and antiviral activity of 5′-acetyl-6′- methyl-2′-thioxo-1′,2′-dihydro-3,4′-bipyridine-3′- carbonitrile
Attaby, Fawzy A.,Ali,Elghandour,Ibrahem, Yasser M.
, p. 1 - 14 (2006)
Bipyridine-3′0-carbonitrile derivatives 5 reacted with several halogen containing reagents, e.g., 1-chloroacetone, 3-chloropentan-2,4-dione, ethyl chloroacetate, ethyl 2-chloro-3-oxobutanoate, 2-chloroacetamide, chloroacetonitrile, and iodomethane to afford the corresponding thieno[2,3-b]-pyridine derivatives. Considering the data of IR, 1H NMR, mass spectra and elemental analysis the chemical structures of the newly synthesized heterocyclic compounds elucidated. Cytotoxicity, anti-HSV1, (anti-Herpes Simplex virus type 1) anti-HAV (Hepatitis A virus), and MBB activity were evaluated for the newly synthesized heterocyclic compounds. Copyright Taylor & Francis LLC.
