132256-95-2

Upstream product

• 4801-58-5 N-hydroxypiperidine 
• 34418-91-2 2,3,4,5-tetrahydropyridine N-oxide 
• 1761-10-0 3-Methyl-indolizin 
• 38198-08-2 3-methyl-hexahydro-indolizin-2-one 
• 78867-41-1 2-(but-3-enyl)piperidine 
• 856099-77-9 (5-methyl-pyrrolidin-2-yl)-acetic acid ethyl ester 
• 4221-03-8 5-hydroxypentanal 
• 132256-91-8 6-(2-Methyl-cyclopropyl)-2,3,4,5-tetrahydro-pyridine 
• 38203-36-0 2-(2-ethoxycarbonylmethyl-piperidin-1-yl)-propionic acid ethyl ester 
• 858274-33-6 3-(2-ethoxycarbonylmethyl-5-methyl-pyrrolidino)-propionic acid ethyl ester 

Relevant academic research and scientific papers

Highly efficient, base-catalysed, intramolecular hydroamination of non-activated olefins

The intramolecular hydroamination of a large variety of non-activated alkenes can be efficiently catalysed by small amounts of lithium bases, providing smoothly and in high yields the corresponding five- and six-membered ring heterocycles. Fused and bridged bicyclic amines, of varying ring sizes, can be readily prepared either by a sequential hydroamination process or by a tandem, double addition reaction.

Reverse Cope Elimination Reactions. 2. Application to Synthesis

Intramolecular addition of N,N-disubstituted hydroxylamines to unactivated olefins was used to prepare an indolizine, a pyrroloisoquinoline, a 1,8-diazaspirodecane, a cyclopentapyrrole, and an isoindoline.A pyrrolizine and a 1-azabicyclo2.

Synthesis of indolidines by the 1,3-dipolar cycloaddition of azides with methylenecyclopropanes followed by cyclopropyumine rearrangement

Cyclic imines 6a and 6b were obtained by the intramolecular 1,3-dipolar cycloaddition of azides with methylenecyclopropanes. Acid catalyzed rearrangement produced bicyclic (-)-enamines 7, which upon reduction provided indoilizidenes 8. A similar strategy was used for the synthesis of (-)-8a-epi-desacctoxyslaframine 16.