1322693-75-3Relevant academic research and scientific papers
Enantioselective friedel-crafts aminoalkylation catalyzed by chiral ammonium 1,1-binaphthyl-2,2-disulfonates
Hatano, Manabu,Sugiura, Yoshihiro,Akakura, Matsujiro,Ishihara, Kazuaki
, p. 1247 - 1250 (2011)
A catalytic enantioselective Friedel-Crafts aminoalkylation between aromatic aldimines and N-benzylpyrrole with the use of a homogeneous chiral ammonium salt, (R)-BINSA-N,N-dimethylbutylamine, as a dynamic Br?nsted acid-Br?nsted base catalyst, is reported. Unlike the results with conventional catalysts, remarkably high reactivity was established at -78 C within 30 minutes, and the corresponding aryl(1H-pyrrol-2-yl)methanamines were obtained with good to high enantioselectivities. Georg Thieme Verlag Stuttgart - New York.
