1322697-71-1Relevant academic research and scientific papers
Switchable synthesis of 3-cyanoindoles and 3-amidylindoles via a palladium-catalyzed reaction of N,N-dimethyl-2-alkynylaniline with isocyanide
Qiu, Guanyinsheng,Qiu, Xiaochen,Liu, Jianping,Wu, Jie
supporting information, p. 2441 - 2446 (2013/10/01)
A palladium-catalyzed reaction of N,N-dimethyl-2-alkynylanilines with isocyanides is reported, leading to the formation of 3-cyanoindoles and 3-amidylindoles. The isocyanide insertion is the key step during the process, and the presence of water is essential for the formation of 3-amidylindoles.
Direct transformation of N, N -dimethylformamide to -CN: Pd-catalyzed cyanation of heteroarenes via C-H functionalization
Ding, Shengtao,Jiao, Ning
supporting information; experimental part, p. 12374 - 12377 (2011/10/02)
This paper describes the direct cyanation of indoles and benzofurans employing N,N-dimethylformamide (DMF) as both reagent and solvent. Isotopic labeling experiments indicated that both the N and the C of the cyano group derived from DMF. This transformation offers an alternative method for preparing aryl nitriles, though it is currently limited in scope to indoles and benzofurans.
