132294-95-2Relevant academic research and scientific papers
Highly enantioselective synthesis of Warfarin and its analogs catalysed by primary amine-phosphinamide bifunctional catalysts
Dong, Juan,Du, Da-Ming
, p. 8125 - 8131 (2012/11/06)
An efficient enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones catalysed by primary amine-phosphinamide bifunctional catalysts has been developed. This reaction afforded Warfarin and its analogs in moderate to excellent yie
Highly effective and enantioselective Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones promoted by simple chiral primary amine thiourea bifunctional catalysts
Mei, Ren-Qiang,Xu, Xiao-Ying,Li, Yan-Chun,Fu, Ji-Ya,Huang, Qing-Chun,Wang, Li-Xin
supporting information; experimental part, p. 1566 - 1568 (2011/05/05)
Highly asymmetric Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketones promoted by chiral primary amine thiourea bifunctional catalysts was developed and a series of Michael adducts were obtained in excellent yields (up to 97%) and enantioselectivities (up to 95% ee). Optically pure S-warfarin was easily obtained in 99% ee after single recrystallization.
