13230-73-4

Usage

Uses

Used in Organic Chemistry:
Acetamide, 2,2,2-trifluoro-N-[2-(4-hydroxyphenyl)ethyl]is used as a building block in organic chemistry for the synthesis of new chemical compounds with specific properties. Its trifluoromethyl and hydroxyphenyl substituents can be utilized to create novel molecules with unique characteristics.
Used in Pharmaceutical Industry:
Acetamide, 2,2,2-trifluoro-N-[2-(4-hydroxyphenyl)ethyl]is used as a potential pharmaceutical candidate in the pharmaceutical industry. Its ability to interact with biological systems makes it a promising compound for the development of new drugs with specific therapeutic effects.
Used in Research and Development:
Acetamide, 2,2,2-trifluoro-N-[2-(4-hydroxyphenyl)ethyl]is used as a subject of interest in research and development for its unique structure and properties. Chemists and biochemists study its interactions with biological systems and explore its potential applications in various fields, including organic chemistry and pharmaceuticals.

Upstream product

• 51-67-2 tyrosamine 
• 407-25-0 trifluoroacetic anhydride 
• 659-34-7 (4-hydroxyphenyl)ethylamine 
• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 
• 76-05-1 trifluoroacetic acid 

Relevant academic research and scientific papers

Photochemical trifluoromethylation of tyramine and L-tyrosine derivatives

Ultraviolet irradation (254 nm) of methanolic solutions of trifluoromethyl iodide (CF3I) in the presence of side-chain-protected tyramine and L-tyrosine results in trifluoromethylation of the aromatic ring.The presence of an amine base to neutralize HI formed during the reaction is essential.The electrophilic trifluoromethyl radical preferentially attacks the ring ortho to the phenolic group, and 3-trifluoromethyltyramine and 3-trifluoromethyl-L-tyrosine derivatives were obtained in yields of 27percent and 33percent, respectively.

NUCLEOTIDE ANALOGUES AND USE THEREOF FOR NUCLEIC ACID SEQUENCING AND ANALYSIS

The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

Computational and Experimental Studies of Phthaloyl Peroxide-Mediated Hydroxylation of Arenes Yield a More Reactive Derivative, 4,5-Dichlorophthaloyl Peroxide

The oxidation of arenes by the reagent phthaloyl peroxide provides a new method for the synthesis of phenols. A new, more reactive arene oxidizing reagent, 4,5-dichlorophthaloyl peroxide, computationally predicted and experimentally determined to possess enhanced reactivity, has expanded the scope of the reaction while maintaining a high level of tolerance for diverse functional groups. The reaction proceeds through a novel "reverse-rebound" mechanism with diradical intermediates. Mechanistic insight was achieved through isolation and characterization of minor byproducts, determination of linear free energy correlations, and computational analysis of substituent effects of arenes, each of which provided additional support for the reaction proceeding through the diradical pathway.