13231-94-2Relevant academic research and scientific papers
A sensitive method for the determination of Sulfonamides in seawater samples by Solid Phase Extraction and UV–Visible spectrophotometry
Errayess, Sophia Ait,Lahcen, Abdellatif Ait,Idrissi, Laila,Marcoaldi, Caterina,Chiavarini, Salvatore,Amine, Aziz
, p. 276 - 285 (2017)
The authors have developed a sensitive spectrophotometric method for determination of sulfonamide derivatives such as sulfanilamide (SAA), sulfadiazine (SDZ), sulfacetamide (SCT) sulfamethoxazole (SMX), sulfamerazine (SMR), sulfadimethoxine (SDX), sulfamethiazole (SMT) and Sulfathiazole (STZ). This method is based on the Bratton-Marshall reaction, which involves the diazotization of sulfonamides with sodium nitrite under acidic conditions, followed by coupling with N-(1-naphtyl) ethylenediamine dihydrochloride (NED) to form a pink colored compound. Therefore, the Bratton-Marshall method was modified by optimizing the reaction conditions, which allows us to determine a low concentration range of sulfonamides compared to the reported methods. The limits of detection and quantification obtained were 0.019–0.05 and 0.06–0.16?μg?mL??1, respectively. In comparison with other reported methods using different coupling agents, the proposed method was found to be the most simple and sensitive for sulfonamides determination. In this paper, the modified method was successfully employed for the determination of sulfonamides in drinking water, seawater and pharmaceutical and veterinary formulations. The purpose of this work is to optimize and develop a simple method for extraction and concentration of sulfonamides present as residues in seawater and their quantification with the recommended spectrophotometric method. Solid phase extraction (SPE) of sulfonamides from seawater samples was evaluated using Oasis HLB cartridges (3?mL, 540?mg). The recovery efficiency was investigated in the sulfonamides concentration range comprised between 0.19 and 126?ng?mL??1. The ease of use of this extraction method makes it very useful for routine laboratory work.
New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols
Eilertsen, Monica,Allin, Steve M.,Pearson, Russell J.
, p. 1106 - 1110 (2018/02/28)
S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.
The synthesis, characterization and biological evaluation of a new nitric oxide donor agent
Profire, Lenuta,Apotrosoaei, Maria,Oprea, Anca,Brebu, Mihai,Lupascu, Florentina,Lupusoru, Catalina Elena,Vasile, Cornelia
, p. 389 - 400 (2014/05/06)
The synthesis of a new xanthine nitric oxide donor (TSP-81) is discussed. The designed compound included two structural moieties, i.e., theophylline (1,3-dimethylxanthine) and acetaminophen (4-hydroxyacetanilide), linked by the nitric oxide donor alkyl chain as a spacer. The compound was characterized by microanalysis (CHN), 1H-NMR, 13C-NMR, FT-IR and UV-Vis spectroscopy and thermogravimetric analysis. The thermal behaviour showed that TSP-81 melts with decomposition in four steps, the most important ones being the 2nd one (the registered weight loss being 17.6 %) and the 3 rd one (with a registered weight loss of 30.4 %). The toxicity degree, the anti-inflammatory effect and the ability of releasing nitric oxide of TSP-81 was also evaluated. The biological assays established that TSP-81 exhibits enhanced biological properties, such as lower toxicity and higher anti-inflammatory effect, compared to theophylline and acetaminophen, the drugs used as the parent molecules. Thus, TSP-81 is approximately 2 times more active than theophylline and 4 times more active than acetaminophen in reducing cotton pellet granuloma formation. Furthermore, the release of nitric oxide (NO) appears to play an important role in enhancing the anti-inflammatory effect.
New spectrophotometric method for the estimation of isosorbide mononitrate in bulk and tablet formulation
Pillai, Anjaly,Pai, P.N. Sanjay
, p. 771 - 775 (2013/11/06)
A validated simple, accurate and rapid spectrophotometric method was developed for the estimation of isosorbide mononitrate in bulk and tablet formulation. The method is based on the reduction of nitrate group of isosorbide mononitrate to nitrite ion by zinc/sodium chloride. Sulphanilamide undergoes diazotization with nitrite ion formed during reduction process in presence of hydrochloric acid. The diazonium salt is then coupled with N-(1-naphthyl) ethylene-diamine dihydrochloride (NED) to form a coloured product which is measured at 540 nm. The method was optimised for the amount of reagents required. Under the optimized experimental condition, Beer's law is obeyed in the concentration range of 5-60 μg ml-1. The average percentage recovery of the drug for the proposed method was found to be in the range of 105.7-106.6% indicating no significant interference from tablet excipients.
