1323141-12-3

Basic information

• Product Name: C₂₂H₂₄N₂O₂
• Synonyms: C₂₂H₂₄N₂O₂
• CAS NO: 1323141-12-3
• Molecular Weight: 348.445
• Mol File: 1323141-12-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₄N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₄N₂O₂(1323141-12-3)
• EPA Substance Registry System: C₂₂H₂₄N₂O₂(1323141-12-3)

Safety Data

• Hazardous Substances Data: 1323141-12-3(Hazardous Substances Data)

Upstream product

• 529-20-4 2-methylphenyl aldehyde 
• 110-89-4 piperidine 
• 53949-13-6 4-(2-methylbenzylidene)-2-phenyloxazol-5-one 

Downstream Products

• 1323140-59-5 (Z)-N-(1-chloro-3-oxo-3-(piperidin-1-yl)-1-o-tolylprop-1-en-2-yl)benzamide 

Relevant articles and documents

Synthesis and quantitative structure-activity relationships study for phenylpropenamide derivatives as inhibitors of hepatitis B virus replication

A series of new phenylpropenamide derivatives containing different substituents was synthesized, characterized and evaluated for their anti-hepatitis B virus (HBV) activities. The quantitative structure eactivity relationships (QSAR) of phenylpropenamide compound have been studied. The 2D-QSAR models, based on DFT and multiple linear regression analysis methods, revealed that higher values of total energy (TE) and lower entropy (Sθ) enhanced the anti-HBV activities of the phenylpropenamide molecules. Predictive 3D-QSAR models were established using SYBYL multifit molecular alignment rule. The optimum models were all statistically significant with cross-validated and conventional coefficients, indicating that they were reliable enough for activity prediction.