1323156-38-2

Basic information

• Product Name: C₃₉H₄₅NO₁₃
• Synonyms: C₃₉H₄₅NO₁₃
• CAS NO: 1323156-38-2
• Molecular Weight: 735.785
• Mol File: 1323156-38-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₉H₄₅NO₁₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₉H₄₅NO₁₃(1323156-38-2)
• EPA Substance Registry System: C₃₉H₄₅NO₁₃(1323156-38-2)

Safety Data

• Hazardous Substances Data: 1323156-38-2(Hazardous Substances Data)

Upstream product

• 10028-45-2 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl bromide 
• 62774-16-7 benzyl 3-O-benzyl-4,6-O-benzylidene-α-D-mannopyranoside 
• 865488-82-0 benzyl 3-O-benzyl-4,6-O-benzylidiene-2-O-[3,4,6-tri-O-acetyl-2-deoxy-2-(N-phthalimido)-β-D-glucopyranosyl]-α-D-mannopyranoside 

Downstream Products

• 865488-85-3 C₃₄H₄₃NO₁₄ 
• 865488-86-4 benzyl 4,6-di-O-acetyl-3-O-benzyl-2-O-[3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosyl]-α-D-mannopyranoside 
• 865488-96-6 2-(p-iodophenyl)ethyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->2)-3,4,6-tri-O-acetyl-α-D-mannopyranosyl-(1->6)-2,3,4-tri-O-acetyl-β-D-glucopyranoside 
• 865488-97-7 2-(p-iodophenyl)ethyl 2-acetamido-2-deoxy-β-D-glucopyranosyl-(1->2)-α-D-mannopyranosyl-(1->6)-β-D-glucopyranoside 
• 865488-84-2 benzyl 3-O-benzyl-4,6-O-benzylidiene-2-O-[3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosyl]-α-D-mannopyranoside 

Relevant articles and documents

Synthesis and evaluation of a radioiodinated trisaccharide derivative as a synthetic substrate for a sensitive N-acetylglucosaminyltransferase v radioassay

N-acetylglucosaminyltransferase V (GnT-V) is one of the most relevant glycosyltransferases to tumor invasion and metastasis. Based on previous findings of molecular recognition between GnT-V and synthetic substrates, we designed and synthesized a p-iodophenyl-derivatized trisaccharide, 2-(4-iodophenyl)ethyl 6-O-[2-O-(2-acetamido-2-deoxy-β-d-glucopyranosyl)- α-d-mannopyranosyl]-β-d-glucopyranoside (IPGMG, 1) and its radiolabeled form, [125I]IPGMG ([125I]1), for use in assays of GnT-V activity in vitro. The tributyltin derivative, 2-[4-(n-tributylstannyl)phenyl]ethyl 6-O-[2-O-(3,4,6-tri-O-acetyl-2-acetamido-2- deoxy-β-d-glucopyranosyl)-3,4,6-tri-O-acetyl-α-d-mannopyranosyl]-2,3, 4-tri-O-acetyl-β-d-glucopyranoside (21), was synthesized as a precursor for the preparation of [125I]1. The iododestannylation of 21 using hydrogen peroxide as an oxidant followed by deacetylation yielded [ 125I]1. When [125I]1 was incubated in GnT-V-expressing cells with a UDP-GlcNAc donor, the production of β1-6GlcNAc-bearing IPGMG (IPGGMG, 2) was confirmed by radio-HPLC. In kinetic analysis, 1 was found to be a good substrate with a Km of 23.7 μM and a Vmax of 159 pmol/h. μg protein. [125I]1 would therefore be a useful synthetic substrate for the quantitative determination of GnT-V activity.