1323310-71-9

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 122-78-1 phenylacetaldehyde 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 124443-33-0 N-((1R,2R)-1-Benzyl-3-hydroxy-2-methyl-propyl)-4-methyl-benzenesulfonamide 
• 1323310-61-7 N-((2R,3R)-2-methyl-1-oxo-4-phenylbutan-3-yl)-p-toluenesulfonamide 
• 717918-03-1 4-methyl-N-(2-phenylethylidene)benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of Benzyl Amines via Copper-Catalyzed Enantioselective Aza-Friedel-Crafts Addition of Phenols to N -Sulfonyl Aldimines

A new copper-catalyzed enantioselective aza-Freidel-Crafts reaction between phenols and N-sulfonyl aldimines that provides chiral secondary benzylamines in good to excellent yields and excellent enantioselectivities (up to 99% ee) is disclosed. In particular, excellent scope with alkylimines was observed for the first time. The synthetic utility of the products was demonstrated in the first enantioselective synthesis of a dual orexin receptor antagonist, a compound that contains an amine-bearing stereocenter adjacent to a bis-ortho-functionalized arene.

PROCESS FOR PRODUCING OPTICALLY ACTIVE BETA-AMINO ALDEHYDE COMPOUND

The invention relates to a method of producing optically active β-aminoaldehyde compound (3) by reacting imine compound (1-1) or sulfone compound (1-2) with aldehyde compound (2) in the presence of an optically active pyrrolidine compound. wherein each sy

Asymmetric Mannich reaction of imines derived from aliphatic and aromatic aldehydes catalyzed by diarylprolinol silyl ether

Anti Mannich, try this! A direct asymmetric Mannich reaction catalyzed by a diarylprolinol silyl ether was developed to afford the anti-Mannich product with excellent enantioselectivity. Imines derived from both aliphatic and aromatic aldehydes were successfully used to obtain the synthetically important β-amino aldehydes (see scheme; Ts=tosyl). The reaction can also be performed in the presence of water. Copyright