132335-49-0

Basic information

• Product Name: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-
• CAS NO: 132335-49-0
• Molecular Formula: C9H15NOS
• Molecular Weight: 185.29
• Mol File: 132335-49-0.mol
• Article Data: 35

Chemical Properties

• CAS DataBase Reference: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-(132335-49-0)
• EPA Substance Registry System: 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)-(132335-49-0)

Safety Data

• Hazardous Substances Data: 132335-49-0(Hazardous Substances Data)

Usage

General Description

2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)- is a chemical compound that consists of a thiophene ring attached to a chiral alpha-(dimethylamino)ethyl side chain. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (R)- has applications in medicinal chemistry, especially in the development of drugs targeting central nervous system disorders and cancer. The (R)-enantiomer of 2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]- is known for its high selectivity and potency in biological activities, making it a valuable tool for drug discovery and development. Additionally, its chiral nature and distinct stereochemistry provide opportunities for the design of novel compounds with improved pharmacokinetic and pharmacodynamic properties.

Upstream product

• 88-15-3 2-Acetylthiophene 
• 13636-02-7 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol 
• 17199-29-0 (S)-Mandelic acid 
• 5424-47-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride 
• 13196-35-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one 
• 34772-98-0 3-dimethylamino-1-thiophen-2-ylpropenone 

Downstream Products

• 287737-72-8 (S)-N,N-dimethyl-N-[3-hydroxy-3-(2-thienyl)propyl]-ammonium (S)-mandelate 
• 13636-02-7 3-(N,N-dimethylamino)-1-(thien-2-yl)propan-1-ol 
• 116817-13-1 duloxetine 
• 116817-79-9 phenyl N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propylcarbamate 
• 132335-47-8 (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate 
• 136434-34-9 duloxetine hydrochloride 
• 132335-46-7 N-methyl-(S)-duloxetine 
• 947686-09-1 (S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine 
• 1369583-87-8 N-[4-(2-methoxyphenylpiperazinyl)propionyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-88-9 N-[4-(3-trifluoromethylphenylpiperazinyl)propionyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-90-3 N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-91-4 N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-93-6 N-[4-(2-methoxyphenylpiperazinyl)propyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-94-7 N-[4-(3-trifluoromethylphenylpiperazinyl)propyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 

Relevant articles and documents

Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof

The invention discloses a tridentate nitrogen phosphine ligand containing arylamine NH as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. The tridentate nitrogen phosphine ligand disclosed by the invention is the first case of tridentate nitrogen phosphine ligand containing not only a quinoline amine structure but also chiral ferrocene at present, a noble metal complex of the type of ligand shows good selectivity and extremely high catalytic activity in an asymmetric hydrogenation reaction, meanwhile, a cheap metal complex of the ligand can also show good selectivity and catalytic activity in the asymmetric hydrogenation reaction, and is very easy to modify in the aspects of electronic effect and space structure, so that the ligand has huge potential application value. A catalyst formed by the ligand and a transition metal complex can be used for catalyzing various reactions, can be used for synthesizing various drugs, and has important industrial application value.

Chiral amino-pyridine-phosphine tridentate ligand, manganese complex, and preparation method and application thereof

The invention discloses a chiral amino-pyridine-phosphine tridentate ligand, a manganese complex, and a preparation method and application thereof. The chiral amino-pyridine-phosphine tridentate ligand is shown as a formula II, and the manganese complex of the chiral amino-pyridine-phosphine tridentate ligand can be used for efficiently catalyzing and hydrogenating ketone compounds to prepare chiral alcohol compounds in a high enantioselectivity mode. The chiral amino-pyridine-phosphine tridentate ligand and the manganese complex are simple in synthesis process, good in stability, high in catalytic activity and mild in reaction conditions.

Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones

A series of MnI complexes containing lutidine-based chiral pincer ligands with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON=turnover number), broad substrate scope (81 examples), good functional-group tolerance, and excellent enantioselectivities (85–98 % ee) in the hydrogenation of various ketones. These aspects are rare in earth-abundant metal catalyzed hydrogenations. The utility of the protocol have been demonstrated in the asymmetric synthesis of a variety of key intermediates for chiral drugs. Preliminary mechanistic investigations indicate that an outer-sphere mode of substrate–catalyst interactions probably dominates the catalysis.