1323723-05-2Relevant academic research and scientific papers
Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines
Kato, Naoya,Shirai, Tomohiko,Yamamoto, Yasunori
supporting information, p. 7739 - 7742 (2016/06/09)
Chiral rhodium(I)-catalyzed highly enantioselective arylation of aliphatic N-sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched α-branched amines (up to 99 % ee). In addition, this system enables efficient synthesis of (+)-NPS R-568 and Cinacalcet which are calcimimetic agents.
Highly enantioselective arylation of N -tosylalkylaldimines catalyzed by rhodium-diene complexes
Cui, Zhe,Yu, Hong-Jie,Yang, Rui-Feng,Gao, Wen-Yun,Feng, Chen-Guo,Lin, Guo-Qiang
supporting information; experimental part, p. 12394 - 12397 (2011/10/02)
A highly enantioselective rhodium-catalyzed arylation of aliphatic N-tosylaldimines has been developed. The combination of chiral bicyclo[3.3.0]octadiene ligands, an active rhodium hydroxide complex, and neutral reaction conditions is the key to achieving high yield and enantioselectivity. The application of this method is demonstrated by the enantioselective synthesis of chiral 2-aryl pyrrolidines and piperidines in a one-pot procedure. Furthermore, excellent results are also obtained for the imine substrates with the more readily cleavable N-nosyl protecting group.
