1323863-85-9Relevant academic research and scientific papers
The immunomodulation potential of the synthetic derivatives of benzothiazoles: Implications in immune system disorders through in vitro and in silico studies
Khan, Khalid Mohammed,Mesaik, Mohammad A.,Abdalla, Omer M.,Rahim, Fazal,Soomro, Samreen,Halim, Sobia A.,Mustafa, Ghulam,Ambreen, Nida,Khalid, Ahmad Shukralla,Taha, Muhammad,Perveen, Shahnaz,Alam, Muhammad Tanveer,Hameed, Abdul,Ul-Haq, Zaheer,Ullah, Hayat,Rehman, Zia Ur,Siddiqui, Rafat Ali,Voelter, Wolfgang
, p. 21 - 28 (2016)
Benzothiazole and its natural or synthetic derivatives have been used as precursors for several pharmacological agents for neuroprotective, anti-bacterial, and anti-allergic activities. The objecctive of the present study was to evaluate effects of benzot
One-Pot Synthesis of Benzothiazole-Tethered Chromanones/Coumarins via Claisen Rearrangement Using the Solid State Melt Reaction
Bakthadoss, Manickam,Selvakumar, Raman
, p. 3391 - 3399 (2016)
A novel protocol has been successfully established for the efficient synthesis of benzothiazole-tethered chromanone/coumarin scaffolds via Claisen rearrangement using a solid state melt reaction in a one-pot manner. Benzothiazole formation and Claisen rearrangement involve the cleavage of S-S and C-O bonds and formation of C-S, C=N, and C-C bonds in a single operation without using a catalyst or solvent.
An ESIPT-based fluorescent probe for highly selective detection of glutathione in aqueous solution and living cells
Ren, Xintong,Wang, Fang,Lv, Jing,Wei, Tingwen,Zhang, Wei,Wang, Yong,Chen, Xiaoqiang
, p. 156 - 162 (2016)
In this paper, highly sensitive and selective fluorescent probe 1 for GSH is designed and synthesized based on modulation of the excited-state intramolecular proton transfer (ESIPT) process of 2-(2′-hydroxy-3′-ethoxyphenyl)benzothiazole. Upon introducing
IMMUNOSUPPRESSIVE COMPOUNDS
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Paragraph 0023, (2015/01/07)
The invention feature series of benzothiazole derivatives as potent immunosuppressive and antiinflammatory agents. Eight compounds 2, 4, 5, 8, 9, 10, 12, and 18 showed potent inhibitory activity on PHA-activated T-cell proliferation. Compounds 2, 4, 8, and 18 were found to have a potent inhibitory activity with IC50 values ranging 50 values 1.9, 5050), respectively.
Synthesis of novel inhibitors of β-glucuronidase based on benzothiazole skeleton and study of their binding affinity by molecular docking
Khan, Khalid Mohammed,Rahim, Fazal,Halim, Sobia Ahsan,Taha, Muhammad,Khan, Momin,Perveen, Shahnaz,Zaheer-Ul-Haq,Mesaik, Muhammad Ahmed,Iqbal Choudhary
experimental part, p. 4286 - 4294 (2011/08/10)
Benzothiazole derivatives 1-26 have been synthesized and their in vitro β-glucuronidase potential has been evaluated. Compounds 4 (IC50 = 8.9 ± 0.25 μM), 5 (IC50 = 36.1 ± 1.80 μM), 8 (IC50 = 8.9 ± 0.38 μM), 13 (IC50/
