132390-61-5

Basic information

• Product Name: 4-ETHOXY-3-NITROBENZALDEHYDE 97
• Synonyms: 4-ETHOXY-3-NITROBENZALDEHYDE 97
• CAS NO: 132390-61-5
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.173
• Product Categories: Aldehydes;C9;Carbonyl Compounds
• Mol File: 132390-61-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 59-63 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 4-ETHOXY-3-NITROBENZALDEHYDE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHOXY-3-NITROBENZALDEHYDE 97(132390-61-5)
• EPA Substance Registry System: 4-ETHOXY-3-NITROBENZALDEHYDE 97(132390-61-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 132390-61-5(Hazardous Substances Data)

Usage

General Description

4-ETHOXY-3-NITROBENZALDEHYDE 97 is a chemical compound with the molecular formula C9H9NO4. It is a yellow crystalline substance that is commonly used as a reagent in organic synthesis and research. 4-ETHOXY-3-NITROBENZALDEHYDE 97 is known for its aromatic and aldehyde properties, making it useful in the production of various organic compounds and dyes. It is also used in the pharmaceutical industry for the synthesis of certain drugs and medications. 4-ETHOXY-3-NITROBENZALDEHYDE 97 is considered a high-purity chemical, with a purity level of 97%, making it suitable for a wide range of applications in the chemical and pharmaceutical industries.

Upstream product

• 10031-82-0 4-ethoxybenzaldehyde 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 75-03-6 ethyl iodide 
• 123-08-0 4-hydroxy-benzaldehyde 
• 74-96-4 ethyl bromide 

Downstream Products

• 1221157-03-4 2-ethoxy-5-(3,4,5-trimethoxyphenethyl)benzenamine 
• 1221157-04-5 2-amino-N-(2-ethoxy-5-(3,4,5-trimethoxyphenethyl)phenyl)acetamide 
• 1334740-34-9 3,4,5-trimethoxyphenyl-3'-amino-4'-ethoxydiphenylethane-Fmoc-glycineamide 
• 1221157-02-3 3,4,5-trimethoxy-3'-nitro-4'-ethoxystilbene 
• 1015697-68-3 (Z)-5-(4-ethoxy-3-nitrostyryl)-1,2,3-trimethoxybenzene 
• 1345962-00-6 1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(4-ethoxy-3-nitrophenyl)imidazole 
• 1345962-05-1 1-methyl-4-(3-bromo-4,5-dimethoxyphenyl)-5-(4-ethoxy-3-nitrophenyl)imidazole 
• 697306-59-5 N-(3-amino-4-ethoxybenzyl)-2,2,2-trifluoro-N-methylacetamide 

Relevant articles and documents

Design, synthesis and anti-proliferative effects in tumor cells of new combretastatin A-4 analogs

Abstract A total of 11 novel combretastatin A-4 (CA-4) analogs were designed, synthesized, and evaluated for the anti-proliferative effects in tumor cells. The compounds represent four structural classes: (i) hydrogenated derivatives, (ii) ethoxyl derivatives, (iii) amino derivatives and (iv) pro-drugs. Biological evaluations demonstrate that multiple structural features control the biological potency. Three of the compounds, sit-1, sit-2 and sit-3, have potent anti-proliferative activity against multiple cancer cell lines. Their pro-drugs were synthesized to increase water solubility. Structure-activity relationship study and Surflex-Docking were studied in this paper. These results will be useful for the design of new CA-4 analogs that are structurally related to the SAR study.

THE PREPARTION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS

The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4'-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3'-position of their B aryl ring. Similarly, 3'-amino combretastatin is 4'-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.

AMINE COMPOUNDS

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.