132392-26-8

Basic information

• Product Name: 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENESULFONYL CHLORIDE
• Synonyms: 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENESULFONYL CHLORIDE;AKOS MSC-0771;5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalen sulfonyl chloride;5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenesulfonyl;5,5,8,8-tetraMethyl-5,6,7,8-tetrahydro-naphthalen-2-sulfonyl chloride;5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenesulfonyl chl;5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride;5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-sulfonyl chloride
• CAS NO: 132392-26-8
• Molecular Formula: C₁₄H₁₉ClO₂S
• Molecular Weight: 286.82
• Mol File: 132392-26-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 78 °C
• Boiling Point: 361.1°Cat760mmHg
• Flash Point: 172.2°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 4.42E-05mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENESULFONYL CHLORIDE(132392-26-8)
• EPA Substance Registry System: 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENESULFONYL CHLORIDE(132392-26-8)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 132392-26-8(Hazardous Substances Data)

Usage

General Description

5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenesulfonyl chloride is an organic compound with the chemical formula C14H21ClO2S. It is a sulfonating reagent used in organic synthesis to introduce the sulfonyl group into various compounds. 5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENESULFONYL CHLORIDE is often used as a reagent in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is a highly reactive and versatile compound that is widely used in the field of organic chemistry for the preparation of a wide range of sulfonyl-containing compounds.

InChI:InChI=1/C14H19ClO2S/c1-13(2)7-8-14(3,4)12-9-10(18(15,16)17)5-6-11(12)13/h5-6,9H,7-8H2,1-4H3

Upstream product

• 110-03-2 2,5-dimethyl-2,5-hexanediol 
• 6223-78-5 2,5-dichloro-2,5-dimethyl hexane 
• 6683-46-1 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydro-naphthalene 

Downstream Products

• 1027995-90-9 4-[Hydroxy-(5,5,8,8-tetramethyl-4-oxo-3,4,5,6,7,8-hexahydro-2H-1-thia-anthracen-3-yl)-methyl]-benzoic acid methyl ester 

Relevant articles and documents

COMPOUNDS AND METHODS FOR INHIBITING CYP26 ENZYMES

Compounds described herein are inhibitors of retinoic acid inducible P450 (CYP26) enzymes, and are useful for treating diseases that are responsive to retinoids. Certain compounds have retinoid activity, are resistant to CYP26-mediated catabolism, and are used for treating diseases that are responsive to retinoids.

TROPOLONE DERIVATIVE

Tropolone derivatives represented by the formula (I), which have retinoid actions and are useful as active ingredients of medicaments [R1 to R4 represent hydrogen atom, an alkyl group, or an alkoxyl group; the ring represented by Ar

A novel type of retinoic acid receptor antagonist: Synthesis and structure-activity relationships of heterocyclic ring-containing benzoic acid derivatives

A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans- retinoic acid were evaluated by in vitro assay systems using human promyelocytic leukemia (HL-60) cells. Structure-activity relationships indicated that both an N-substituted pyrrole or pyrazole (1-position) and a hydrophobic region, with these linked by a ring system, were indispensable for effective antagonism. Among the compounds evaluated, optimal antagonism was exhibited by 4-[4,5,7,8,9,10-hexahydro-7,7,10,-10-tetramethyl-1-(3- pyridylmethyl)anthra[1,2-b]pyrrol-3-yl]benzoic acid (31), 4-[4,5,7,8,9,10- hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)-5-thiaanthra[1,2- b]pyrrol-3-yl]benzoic acid (40), and 4-[4,5,7,8,9,10-hexahydro-7,7,10,10- tetramethyl-1-(3-pyridylmethyl)anthra[2,1-d]pyrazol-3-yl]benzoic acid (55), all of which possess a 3-pyridylmethyl group at the five-membered ring nitrogen atom.