1323921-51-2

Upstream product

• 62-53-3 aniline 
• 941-69-5 N-phenyl-maleimide 
• 503607-26-9 ethyl 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)acetate 

Relevant academic research and scientific papers

Dual organic dyes as a pseudo-redox mediation system to promotion of tandem oxidation /[3+2] cycloaddition reactions under visible light

An atom- and step-economy protocol has been developed to synthesize some new biologically active pyrrolo[2,1-a]isoquinoline alkaloids via redox mediation system under visible light irradiation. A vast variety of double and triple bonds, as dipolarophiles, treated with in situ generated azomethine ylides to prepare corresponding products in good to excellent yields. This metal-free method effectively promoted oxidation/[3 + 2] cycloaddition/oxidative/aromatization domino reaction without further oxidant using dual organic dyes as pseudo-redox mediation system. Besides, for most of the products, product precipitate was readily separated from reaction media. To the best of our knowledge, this is the first report of dual dyes as a pseudo-redox mediation system.

Chlorophyll-catalyzed tandem oxidation /[3+2] cycloaddition reactions toward the construction of pyrrolo[2,1-a]isoquinolines under visible light

Chlorophyll as a green, cheap, and affordable natural pigment was used in the one-pot synthesis of pyrrolo[2,1-a]isoquinoline scaffold under visible light. This photocatalytic approach has handled oxidation/[3 + 2] cycloaddition/aromatization cascade reac

CuBr/NHPI co-catalyzed aerobic oxidative [3 + 2] cycloaddition-aromatization to access 5,6-dihydro-pyrrolo[2,1-: A] isoquinolines

An efficient and enviromentally friendly CuBr/NHPI co-catalyzed aerobic oxidative [3 + 2] cycloaddition-aromatization cascade was realized with N-substituted tetrahydroisoquinolines and electron-deficient olefins. Under the mild conditions, the reaction p

Pyrrole [2,1-a] isoquinoline alkaloid and preparation method and application thereof

The invention discloses pyrrole [2,1-a] isoquinoline alkaloid and a preparation method and medical application thereof, and belongs to the field of medicinal chemistry. The structural general formula of the pyrrole [2,1-a] isoquinoline alkaloid is as show

A general, simple and green process to access pyrrolo[2,1-a]isoquinolines using a KI/TBHP catalytic system

A novel KI/TBHP-catalyzed 1,3-dipolar cycloaddition/oxidation/aromatization cascade reaction provided general, efficient and green access to biologically important pyrrolo[2,1-a]isoquinolines. The product pyrrolo[2,1-a]isoquinolines were obtained from rea

Iodine-catalyzed 1,3-dipolar cycloaddition/oxidation/aromatization cascade with hydrogen peroxide as the terminal oxidant: General route to pyrrolo[2,1- a ]isoquinolines

We report a novel molecular iodine-catalyzed 1,3-dipolar cycloaddition/oxidation/aromatization cascade process with hydrogen peroxide as the terminal oxidant for the construction of pyrrolo[2,1-a]isoquinolines. The product pyrrolo[2,1-a]isoquinolines were

Synthesis of 3,4-dihydropyrrolo[2,1-a]isoquinolines based on [3+2] cycloaddition initiated by Rh2(cap)4-catalyzed oxidation

Azomethine ylides have been efficiently generated via Rh 2(cap)4-catalyzed oxidation of tetrahydroisoquinoline derivatives in the presence of base. The ylides are trapped in situ via [3+2] cycloaddition with dipolarophiles and subjec

Visible-light-induced oxidation/[3+2] cycloaddition/oxidative aromatization sequence: A photocatalytic strategy to construct pyrrolo[2,1-a]isoquinolines

A ray of sunshine: The title reaction sequence using ethyl 2-(3,4-dihydroisoquinolin-2(1H)-yl)acetates with a series of electron-deficient alkenes and alkynes provides rapid and efficient access to pyrrolo[2,1-a] isoquinolines (see scheme; bpy=2,2′-bipyri