1323951-63-8

Basic information

• Product Name: 3-(4-(trifluoromethyl)phenyl)-2H-chromen-2-one
• Synonyms: 3-(4-(trifluoromethyl)phenyl)-2H-chromen-2-one
• CAS NO: 1323951-63-8
• Molecular Weight: 290.241
• Mol File: 1323951-63-8.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-(trifluoromethyl)phenyl)-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(trifluoromethyl)phenyl)-2H-chromen-2-one(1323951-63-8)
• EPA Substance Registry System: 3-(4-(trifluoromethyl)phenyl)-2H-chromen-2-one(1323951-63-8)

Safety Data

• Hazardous Substances Data: 1323951-63-8(Hazardous Substances Data)

Upstream product

• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 68-12-2 N,N-dimethyl-formamide 
• 2338-75-2 4-(Trifluoromethyl)phenylacetonitrile 
• 201230-82-2 carbon monoxide 
• 90-02-8 salicylaldehyde 
• 939-99-1 4-trifluoromethylbenzyl chloride 
• 705-31-7 4-trifluoromethylphenylacetylene 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 91-64-5 coumarin 

Relevant articles and documents

A complete switch of the directional selectivity in the annulation of 2-hydroxybenzaldehydes with alkynes

Controlling reaction selectivity is an eternal pursuit for chemists working in chemical synthesis. As part of this endeavor, our group has been exploring the possibility of constructing different natural product skeletons from the same simple starting mat

KMnO4/AcOH-mediated C3-selective direct arylation of coumarins with arylboronic acids

An efficient protocol for KMnO4/AcOH-mediated dehydrogenative direct radical arylation of coumarins with arylboronic acids to afford 3-arylcoumarin derivatives is described. A similar reaction system is also applicable to the 3-arylation of quinolinone derivatives. These KMnO4/AcOH-mediated coupling reactions occur regioselectively at the C3 position of coumarins and quinolinones. Some notable features of this method are high efficiency, moderate to good yield, and a broad group tolerance.

A general palladium-catalyzed carbonylative synthesis of chromenones from salicylic aldehydes and benzyl chlorides

Cute CO! An interesting and straightforward procedure for the carbonylative synthesis of chromenones from readily available salicylic aldehydes and benzyl chlorides has been developed (see scheme; DPPP=1,3-bis(diphenylphosphino) propane). In the presence of a palladium catalyst, various coumarins were produced in good to excellent yields. Copyright

Three-component coupling using arynes and DMF: Straightforward access to coumarins via ortho-quinone methides

ortho-Quinone methides, arising from a formal [2+2] cycloaddition between arynes and DMF, were found to facilely undergo a [4+2] cycloaddition with ester enolates or ketenimine anions to produce diverse coumarins in a straightforward manner. The Royal Society of Chemistry 2011.