1323975-46-7Relevant academic research and scientific papers
One-Pot Synthesis of Pyrrolo[1,2- a ]quinoxaline Derivatives via a Copper-Catalyzed Aerobic Oxidative Domino Reaction
Liu, Huanhuan,Duan, Tiantian,Zhang, Zeyuan,Xie, Caixia,Ma, Chen
supporting information, p. 2932 - 2935 (2015/06/30)
A copper-catalyzed process for the synthesis of pyrrolo[1,2-a]quinoxalines from readily available α-amino acids and 1-(2-halophenyl)-1H-pyrroles is described. Different functional groups were well tolerated to give the corresponding products.
Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade
Baumann, Marcus,Baxendale, Ian R.
, p. 10806 - 10816 (2015/11/18)
An efficient reaction cascade delivering a series of pyrrolo[1,2-a]quinolines bearing phosphonate or phosphine oxide moieties is presented. This sequence exploits the in situ transformation of propargylic alcohols into transient allenes by means of a strategic [2,3]-sigmatropic rearrangement followed by trapping of the resulting allenes by an adjacent pyrrole ring. Furthermore, the initial small scale batch process was successfully translated into a continuous flow process allowing efficient preparation of selected pyrrolo[1,2-a]quinolines on multigram scale without any safety concerns due to the reaction's inherent exothermic profile.
Expeditious synthesis of tetrasubstituted helical alkenes by a cascade of palladium-catalyzed C-H activations
Liu, Hongqiang,El-Salfiti, Mohamed,Lautens, Mark
supporting information, p. 9846 - 9850 (2012/11/07)
Twisted molecules: A modular approach for the synthesis of tetrasubstituted helical alkenes by a palladium-catalyzed norbornene-mediated domino reaction is presented. This intermolecular domino process allows the formation of three C-C bonds in one operation through a C-H activation/carbopalladation/C-H activation sequence. Copyright
Mechanistic studies of Pd-catalyzed regioselective aryl C-H bond functionalization with strained alkenes: Origin of regioselectivity
Chai, David I.,Thansandote, Praew,Lautens, Mark
supporting information; experimental part, p. 8175 - 8188 (2011/09/14)
Mechanistic studies of a palladium-catalyzed regioselective aryl C-H functionalization of 2-pyrrole phenyl iodide with norbornene are presented. Kinetic and spectroscopic analyses together with crystallographic data provide evidence for intermediates in a
