1324006-05-4Relevant academic research and scientific papers
An enantioselective Mukaiyama aldol reaction as the key step towards the tetrahydropyran core of psymberin via a γ-butyrolactone intermediate
Bielitza, Max,Pietruszka, J?rg
, p. 1625 - 1628 (2012)
We report an alternative synthetic route towards the tetrahydropyran core of psymberin. The key steps are a catalytic enantioselective Mukaiyama aldol reaction and a syn reduction, which allowed for the rapid assembly of a γ-lactone as a precursor for the central fragment of the natural product. Georg Thieme Verlag Stuttgart · New York.
Synthesis of 8-desmethoxy psymberin: A putative biosynthetic intermediate towards the marine polyketide psymberin
Bielitza, Max,Pietruszka, J?rg
supporting information, p. 8300 - 8308 (2013/07/25)
The synthesis of a putative biosynthetic precursor of psymberin including a formal synthesis of the natural product is described. The key step towards the densely functionalized tetrahydropyran core was an enantioselective catalytic Mukaiyama aldol reacti
